Clobazam and Cannabidiol Interaction
Drug interaction information between Clobazam and Cannabidiol.
Clobazam and Cannabidiol have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Clobazam and Cannabidiol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Cannabidiol increases the amount of an active byproduct of clobazam in your blood, which can lead to more side effects.
FDA Label Information
7.2 Effect of EPIDIOLEX on Other Drugs Antiepileptic Drugs Clobazam Concomitant use of EPIDIOLEX with clobazam increases plasma concentrations of N‑desmethylclobazam, the active metabolite of clobazam [see Clinical Pharmacology ( 12.3 )], which may increase the risk of clobazam-related adverse reactions [see Adverse Reactions ( 6.1 ) and Warnings and Precautions ( 5.1 , 5.2 )]. Consider a reduction in dosage of clobazam if adverse reactions known to occur with clobazam are experienced when concomitantly used with EPIDIOLEX.
Clobazam Also Interacts With
- Cenobamate moderate
- Omeprazole minor
- Fluconazole minor
- Fluvoxamine minor
- Lisdexamfetamine minor
Cannabidiol Also Interacts With
- Clopidogrel minor
- Tizanidine minor
- Valproate minor
- Rifampin minor
- Digoxin minor
Frequently Asked Questions
What SPL severity band is on file for Clobazam + Cannabidiol?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cannabidiol has 8 labeled pairs on file vs Clobazam's 6. In the moderate band specifically: Clobazam has 2 (also Cenobamate); Cannabidiol has 1.
What mechanism field is on file for Clobazam and Cannabidiol?
Cannabidiol increases the amount of an active byproduct of clobazam in your blood, which can lead to more side effects.
Cannabidiol's labeled portfolio outnumbers Clobazam
SPL source-record counts only. This page's band is moderate · classes on file: Clobazam (Benzodiazepine (Anticonvulsant)); Cannabidiol (Cannabinoid (Anticonvulsant)).
0 major · 1 moderate · 7 minor · 8 total
Cannabidiol has no other moderate-band peer in this dataset besides Clobazam.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.