Clobazam and Cenobamate Interaction
Drug interaction information between Clobazam and Cenobamate.
Clobazam and Cenobamate have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Clobazam and Cenobamate. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Cenobamate increases the level of the active part of clobazam in your bloodstream. This can lead to more side effects from the clobazam.
FDA Label Information
( 7.1 ) Phenobarbital and Clobazam: Reduce dosage as needed when used concomitantly with XCOPRI. phenobarbital ↑ plasma concentrations Because of a potential for an increase in the risk of adverse reactions from these drugs, consider a reduction in dosage of phenobarbital or clobazam, as clinically appropriate, when used concomitantly with XCOPRI. desmethylclobazam, the active metabolite of clobazam ↑ plasma concentrations CYP2B6 Substrates ↓ plasma concentrations Because of a potential for reduced efficacy of these drugs, increase the dosage of CYP2B6 or CYP3A4 substrates, as needed, when...
Clobazam Also Interacts With
- Cannabidiol moderate
- Omeprazole minor
- Fluconazole minor
- Fluvoxamine minor
- Lisdexamfetamine minor
Cenobamate Also Interacts With
- Phenobarbital moderate
- Lamotrigine minor
- Carbamazepine minor
- Phenytoin minor
Frequently Asked Questions
What SPL severity band is on file for Clobazam + Cenobamate?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clobazam has 6 labeled pairs on file vs Cenobamate's 5. In the moderate band specifically: Clobazam has 2 (also Cannabidiol); Cenobamate has 2 (also Phenobarbital).
What mechanism field is on file for Clobazam and Cenobamate?
Cenobamate increases the level of the active part of clobazam in your bloodstream. This can lead to more side effects from the clobazam.
Clobazam's labeled portfolio outnumbers Cenobamate
SPL source-record counts only. This page's band is moderate · classes on file: Clobazam (Benzodiazepine (Anticonvulsant)); Cenobamate (Anticonvulsant).
0 major · 2 moderate · 3 minor · 5 total
- Other moderate peers for Cenobamate
- Phenobarbital
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.