Clobazam and Fluconazole Interaction
Drug interaction information between Clobazam and Fluconazole.
Clobazam and Fluconazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Clobazam and Fluconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Fluconazole blocks the specific enzyme that clears clobazam from your system. This makes the clobazam stay in your body longer and can increase its effects.
FDA Label Information
Dosage adjustment of clobazam oral suspension may be necessary when co-administered with strong CYP2C19 inhibitors (e.g., fluconazole, fluvoxamine, ticlopidine) or moderate CYP2C19 inhibitors (e.g., omeprazole) [see Clinical Pharmacology ( 12.3 )].
Clobazam Also Interacts With
- Cannabidiol moderate
- Cenobamate moderate
- Omeprazole minor
- Fluvoxamine minor
- Lisdexamfetamine minor
Fluconazole Also Interacts With
- Pimozide major
- Clarithromycin major
- Eplerenone major
- Atorvastatin moderate
- Simvastatin moderate
Frequently Asked Questions
What SPL severity band is on file for Clobazam + Fluconazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluconazole has 67 labeled pairs on file vs Clobazam's 6. In the minor band specifically: Clobazam has 4 (also Omeprazole, Fluvoxamine, Lisdexamfetamine); Fluconazole has 57 (also Amlodipine, Losartan, Hydrochlorothiazide, Meloxicam).
What mechanism field is on file for Clobazam and Fluconazole?
Fluconazole blocks the specific enzyme that clears clobazam from your system. This makes the clobazam stay in your body longer and can increase its effects.
Fluconazole carries more major-labeled pairs than Clobazam
SPL source-record counts only. This page's band is minor · classes on file: Clobazam (Benzodiazepine (Anticonvulsant)); Fluconazole (Azole Antifungal).
Fluconazole has 3 major-labeled pairs vs Clobazam's 0. This page itself is in the minor band, not the major band.
0 major · 2 moderate · 4 minor · 6 total
- Other minor peers for Clobazam
- Omeprazole
- Fluvoxamine
- Lisdexamfetamine
3 major · 7 moderate · 57 minor · 67 total
- Other minor peers for Fluconazole
- Amlodipine
- Losartan
- Hydrochlorothiazide
- Meloxicam
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.