What the FDA labels say about taking them together
Clobazam and fluconazole
Clobazam's FDA label of March 12, 2024 names fluconazole in its drug interactions section; fluconazole's label does not name clobazam itself but warns about its class (Benzodiazepines). The clobazam label: “Dosage adjustment of ONFI may be necessary when co-administered with strong CYP2C19 inhibitors or moderate CYP2C19 inhibitors (e.g., omeprazole).”
Check it at the source: the clobazam FDA label on DailyMed (effective March 12, 2024, Lundbeck Pharmaceuticals LLC); the fluconazole FDA label on DailyMed (effective April 7, 2026, Zydus Pharmaceuticals (USA) Inc.).
What does the clobazam label say about fluconazole?
Clobazam label, drug interactionsDosage adjustment of ONFI may be necessary when co-administered with strong CYP2C19 inhibitors (e.g., fluconazole, fluvoxamine, ticlopidine) or moderate CYP2C19 inhibitors (e.g., omeprazole) [see Clinical Pharmacology ( 12.3 )].
Source: FDA drug label (Sympazan, NDA210833), Aquestive Therapeutics, effective December 1, 2025 (SPL set 5e3d8fcb-aa7d-4822-88fc-4f06264c3242), via openFDA
Source: FDA drug label (Onfi), Lundbeck Pharmaceuticals LLC, effective March 12, 2024 (SPL set de03bd69-2dca-459c-93b4-541fd3e9571c), via openFDA; the full label on DailyMed
What does the fluconazole label say about clobazam?
Fluconazole's label does not name clobazam itself; it warns about its class (Benzodiazepines):
Fluconazole label, drug interactionsShort-acting benzodiazepines Following oral administration of midazolam, fluconazole resulted in substantial increases in midazolam concentrations and psychomotor effects.
Fluconazole label, drug interactionsIf short-acting benzodiazepines, which are metabolized by the cytochrome P450 system, are concomitantly administered with fluconazole, consideration should be given to decreasing the benzodiazepine dosage, and the patients should be appropriately monitored. (See
Source: FDA drug label (fluconazole), Zydus Pharmaceuticals (USA) Inc., effective April 7, 2026 (SPL set d1364455-1537-46d4-b093-38cca3be778f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Clobazam | Fluconazole | |
|---|---|---|
| Labeled for | n/a | Fungal infections, Urinary tract infections |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.243 per tablet 10 mg tablet | $0.380 per tablet 200 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once