Clobazam and Fluvoxamine Interaction
Drug interaction information between Clobazam and Fluvoxamine.
Clobazam and Fluvoxamine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Clobazam and Fluvoxamine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Fluvoxamine interferes with how your body breaks down clobazam. This can lead to a buildup of clobazam in your bloodstream.
FDA Label Information
Dosage adjustment of clobazam oral suspension may be necessary when co-administered with strong CYP2C19 inhibitors (e.g., fluconazole, fluvoxamine, ticlopidine) or moderate CYP2C19 inhibitors (e.g., omeprazole) [see Clinical Pharmacology ( 12.3 )].
Clobazam Also Interacts With
- Cannabidiol moderate
- Cenobamate moderate
- Omeprazole minor
- Fluconazole minor
- Lisdexamfetamine minor
Fluvoxamine Also Interacts With
- Tizanidine major
- Lithium moderate
- Phenelzine moderate
- Tasimelteon moderate
- Metoprolol minor
Frequently Asked Questions
What SPL severity band is on file for Clobazam + Fluvoxamine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluvoxamine has 40 labeled pairs on file vs Clobazam's 6. In the minor band specifically: Clobazam has 4 (also Omeprazole, Fluconazole, Lisdexamfetamine); Fluvoxamine has 36 (also Metoprolol, Omeprazole, Fluoxetine, Aspirin).
What mechanism field is on file for Clobazam and Fluvoxamine?
Fluvoxamine interferes with how your body breaks down clobazam. This can lead to a buildup of clobazam in your bloodstream.
Fluvoxamine carries more major-labeled pairs than Clobazam
SPL source-record counts only. This page's band is minor · classes on file: Clobazam (Benzodiazepine (Anticonvulsant)); Fluvoxamine (Selective Serotonin Reuptake Inhibitor (SSRI)).
Fluvoxamine has 1 major-labeled pair vs Clobazam's 0. This page itself is in the minor band, not the major band.
0 major · 2 moderate · 4 minor · 6 total
- Other minor peers for Clobazam
- Omeprazole
- Fluconazole
- Lisdexamfetamine
1 major · 3 moderate · 36 minor · 40 total
- Other minor peers for Fluvoxamine
- Metoprolol
- Omeprazole
- Fluoxetine
- Aspirin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.