Clobazam and Omeprazole Interaction
Drug interaction information between Clobazam and Omeprazole.
Clobazam and Omeprazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Clobazam and Omeprazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Omeprazole slows down the liver's ability to process clobazam. This can cause the amount of clobazam in your body to rise to higher levels.
FDA Label Information
Dosage adjustment of clobazam oral suspension may be necessary when co-administered with strong CYP2C19 inhibitors (e.g., fluconazole, fluvoxamine, ticlopidine) or moderate CYP2C19 inhibitors (e.g., omeprazole) [see Clinical Pharmacology ( 12.3 )].
Clobazam Also Interacts With
- Cannabidiol moderate
- Cenobamate moderate
- Fluconazole minor
- Fluvoxamine minor
- Lisdexamfetamine minor
Omeprazole Also Interacts With
- Theophylline major
- Clarithromycin moderate
- Clopidogrel moderate
- Darunavir moderate
- Tacrolimus Topical moderate
Frequently Asked Questions
What SPL severity band is on file for Clobazam + Omeprazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Omeprazole has 27 labeled pairs on file vs Clobazam's 6. In the minor band specifically: Clobazam has 4 (also Fluconazole, Fluvoxamine, Lisdexamfetamine); Omeprazole has 22 (also Aripiprazole, Atomoxetine, Brexpiprazole, Carbamazepine).
What mechanism field is on file for Clobazam and Omeprazole?
Omeprazole slows down the liver's ability to process clobazam. This can cause the amount of clobazam in your body to rise to higher levels.
Omeprazole carries more major-labeled pairs than Clobazam
SPL source-record counts only. This page's band is minor · classes on file: Clobazam (Benzodiazepine (Anticonvulsant)); Omeprazole (Proton Pump Inhibitor (PPI)).
Omeprazole has 1 major-labeled pair vs Clobazam's 0. This page itself is in the minor band, not the major band.
0 major · 2 moderate · 4 minor · 6 total
- Other minor peers for Clobazam
- Fluconazole
- Fluvoxamine
- Lisdexamfetamine
1 major · 4 moderate · 22 minor · 27 total
- Other minor peers for Omeprazole
- Aripiprazole
- Atomoxetine
- Brexpiprazole
- Carbamazepine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.