Clobazam and Omeprazole Interaction
Drug interaction information between Clobazam and Omeprazole.
Clobazam and Omeprazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Clobazam and Omeprazole. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Omeprazole slows down the liver's ability to process clobazam. This can cause the amount of clobazam in your body to rise to higher levels.
What To Do
Your doctor may need to lower your clobazam dose while you are taking omeprazole. Watch for increased side effects like extreme sleepiness.
FDA Label Information
Dosage adjustment of clobazam oral suspension may be necessary when co-administered with strong CYP2C19 inhibitors (e.g., fluconazole, fluvoxamine, ticlopidine) or moderate CYP2C19 inhibitors (e.g., omeprazole) [see Clinical Pharmacology ( 12.3 )].
Clobazam Also Interacts With
- Cannabidiol moderate
- Cenobamate moderate
- Fluconazole minor
- Fluvoxamine minor
- Lisdexamfetamine minor
Omeprazole Also Interacts With
- Theophylline major
- Clarithromycin moderate
- Clopidogrel moderate
- Darunavir moderate
- Tacrolimus Topical moderate
Frequently Asked Questions
Can I take Clobazam and Omeprazole together?
This is a minor interaction. Your doctor may need to lower your clobazam dose while you are taking omeprazole. Watch for increased side effects like extreme sleepiness.
How serious is the interaction between Clobazam and Omeprazole?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Clobazam and Omeprazole interact?
Omeprazole slows down the liver's ability to process clobazam. This can cause the amount of clobazam in your body to rise to higher levels.
Understanding the Clobazam and Omeprazole Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Clobazam belongs to the Benzodiazepine (Anticonvulsant) class and Omeprazole belongs to the Proton Pump Inhibitor (PPI) class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Omeprazole slows down the liver's ability to process clobazam. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Clobazam has 6 total documented interactions on file in this dataset, and Omeprazole has 27. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your doctor may need to lower your clobazam dose while you are taking omeprazole. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Clobazam or Omeprazole based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.