What the FDA labels say about taking them together
Clobazam and omeprazole
Clobazam's FDA label of March 12, 2024 names omeprazole in its drug interactions section; the omeprazole labels PlainMeds reads (2) do not name clobazam. The clobazam label: “Dosage adjustment of ONFI may be necessary when co-administered with strong CYP2C19 inhibitors or moderate CYP2C19 inhibitors (e.g., omeprazole).”
Check it at the source: the clobazam FDA label on DailyMed (effective March 12, 2024, Lundbeck Pharmaceuticals LLC); the omeprazole FDA label on DailyMed (effective April 22, 2024, Apotex Corp).
What does the clobazam label say about omeprazole?
Clobazam label, drug interactionsDosage adjustment of ONFI may be necessary when co-administered with strong CYP2C19 inhibitors (e.g., fluconazole, fluvoxamine, ticlopidine) or moderate CYP2C19 inhibitors (e.g., omeprazole) [see Clinical Pharmacology ( 12.3 )].
Source: FDA drug label (Sympazan, NDA210833), Aquestive Therapeutics, effective December 1, 2025 (SPL set 5e3d8fcb-aa7d-4822-88fc-4f06264c3242), via openFDA
Source: FDA drug label (Onfi), Lundbeck Pharmaceuticals LLC, effective March 12, 2024 (SPL set de03bd69-2dca-459c-93b4-541fd3e9571c), via openFDA; the full label on DailyMed
What does the omeprazole label say about clobazam?
Omeprazole's label (effective April 22, 2024) and its 1 other brand-application label do not name clobazam in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Omeprazole), Apotex Corp, effective April 22, 2024 (SPL set b83329ac-a65e-b3af-a3fb-c5a6c740e5e7), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Clobazam | Omeprazole | |
|---|---|---|
| Labeled for | n/a | Acid reflux and ulcers |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.243 per tablet 10 mg tablet | $0.0295 per capsule 20 mg capsule |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once