Cannabidiol and Rifampin Interaction
Drug interaction information between Cannabidiol and Rifampin.
Cannabidiol and Rifampin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Cannabidiol and Rifampin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Rifampin makes your body clear cannabidiol much faster than usual, which makes the medicine less effective.
FDA Label Information
( 7.2 ) 7.1 Effect of Other Drugs on EPIDIOLEX Strong CYP3A4 or CYP2C19 Inducers Concomitant use with a strong CYP3A4 and CYP2C19 inducer (rifampin 600 mg once daily) decreased cannabidiol and 7‑OH‑CBD plasma concentrations by approximately 32% and 63%.
Cannabidiol Also Interacts With
- Clobazam moderate
- Clopidogrel minor
- Tizanidine minor
- Valproate minor
- Digoxin minor
Rifampin Also Interacts With
- Darunavir major
- Bictegravir/Emtricitabine/Tenofovir major
- Glecaprevir/Pibrentasvir major
- Nirmatrelvir/Ritonavir major
- Pitavastatin major
Frequently Asked Questions
What SPL severity band is on file for Cannabidiol + Rifampin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Rifampin has 137 labeled pairs on file vs Cannabidiol's 8. In the minor band specifically: Cannabidiol has 7 (also Clopidogrel, Tizanidine, Valproate, Digoxin); Rifampin has 103 (also Metoprolol, Losartan, Simvastatin, Glipizide).
What mechanism field is on file for Cannabidiol and Rifampin?
Rifampin makes your body clear cannabidiol much faster than usual, which makes the medicine less effective.
Rifampin carries more major-labeled pairs than Cannabidiol
SPL source-record counts only. This page's band is minor · classes on file: Cannabidiol (Cannabinoid (Anticonvulsant)); Rifampin (Rifamycin Antibiotic).
Rifampin has 8 major-labeled pairs vs Cannabidiol's 0. This page itself is in the minor band, not the major band.
0 major · 1 moderate · 7 minor · 8 total
- Other minor peers for Cannabidiol
- Clopidogrel
- Tizanidine
- Valproate
- Digoxin
8 major · 26 moderate · 103 minor · 137 total
- Other minor peers for Rifampin
- Metoprolol
- Losartan
- Simvastatin
- Glipizide
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.