Cannabidiol and Digoxin Interaction
Drug interaction information between Cannabidiol and Digoxin.
Cannabidiol and Digoxin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Cannabidiol and Digoxin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Cannabidiol can block a protein that helps remove digoxin from your body, causing the drug to build up to higher levels.
FDA Label Information
Increases in exposure of other orally administered P‑gp substrates (e.g., sirolimus, tacrolimus, digoxin) may be observed when concomitantly used with EPIDIOLEX.
Cannabidiol Also Interacts With
- Clobazam moderate
- Clopidogrel minor
- Tizanidine minor
- Valproate minor
- Rifampin minor
Digoxin Also Interacts With
- Nicardipine major
- Posaconazole major
- Sotalol moderate
- Dofetilide moderate
- Ivabradine moderate
Frequently Asked Questions
What SPL severity band is on file for Cannabidiol + Digoxin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Digoxin has 120 labeled pairs on file vs Cannabidiol's 8. In the minor band specifically: Cannabidiol has 7 (also Clopidogrel, Tizanidine, Valproate, Rifampin); Digoxin has 105 (also Metformin, Omeprazole, Ibuprofen, Diclofenac).
What mechanism field is on file for Cannabidiol and Digoxin?
Cannabidiol can block a protein that helps remove digoxin from your body, causing the drug to build up to higher levels.
Digoxin carries more major-labeled pairs than Cannabidiol
SPL source-record counts only. This page's band is minor · classes on file: Cannabidiol (Cannabinoid (Anticonvulsant)); Digoxin (Cardiac Glycoside).
Digoxin has 2 major-labeled pairs vs Cannabidiol's 0. This page itself is in the minor band, not the major band.
0 major · 1 moderate · 7 minor · 8 total
- Other minor peers for Cannabidiol
- Clopidogrel
- Tizanidine
- Valproate
- Rifampin
2 major · 13 moderate · 105 minor · 120 total
- Other minor peers for Digoxin
- Metformin
- Omeprazole
- Ibuprofen
- Diclofenac
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.