Cannabidiol and Clopidogrel Interaction
Drug interaction information between Cannabidiol and Clopidogrel.
Cannabidiol and Clopidogrel have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Cannabidiol and Clopidogrel. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Cannabidiol interferes with how your body activates clopidogrel, which can make the medicine less effective at preventing blood clots.
FDA Label Information
For CYP2C19 substrates (e.g., clopidogrel) where efficacy is mainly due to their active metabolite(s), concomitant use of EPIDIOLEX may decrease plasma concentration of the active metabolite(s) and may therefore decrease efficacy.
Cannabidiol Also Interacts With
- Clobazam moderate
- Tizanidine minor
- Valproate minor
- Rifampin minor
- Digoxin minor
Clopidogrel Also Interacts With
- Omeprazole moderate
- Warfarin moderate
- Esomeprazole moderate
- Rifampin moderate
- Norepinephrine moderate
Frequently Asked Questions
What SPL severity band is on file for Cannabidiol + Clopidogrel?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clopidogrel has 19 labeled pairs on file vs Cannabidiol's 8. In the minor band specifically: Cannabidiol has 7 (also Tizanidine, Valproate, Rifampin, Digoxin); Clopidogrel has 10 (also Morphine, Repaglinide, Lansoprazole, Dexlansoprazole).
What mechanism field is on file for Cannabidiol and Clopidogrel?
Cannabidiol interferes with how your body activates clopidogrel, which can make the medicine less effective at preventing blood clots.
Clopidogrel's labeled portfolio outnumbers Cannabidiol
SPL source-record counts only. This page's band is minor · classes on file: Cannabidiol (Cannabinoid (Anticonvulsant)); Clopidogrel (Antiplatelet Agent).
0 major · 1 moderate · 7 minor · 8 total
- Other minor peers for Cannabidiol
- Tizanidine
- Valproate
- Rifampin
- Digoxin
0 major · 9 moderate · 10 minor · 19 total
- Other minor peers for Clopidogrel
- Morphine
- Repaglinide
- Lansoprazole
- Dexlansoprazole
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.