Cannabidiol and Clopidogrel Interaction
Drug interaction information between Cannabidiol and Clopidogrel.
Cannabidiol and Clopidogrel have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Cannabidiol and Clopidogrel. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Cannabidiol interferes with how your body activates clopidogrel, which can make the medicine less effective at preventing blood clots.
What To Do
Your doctor may need to adjust your treatment to make sure your medicine is still working correctly.
FDA Label Information
For CYP2C19 substrates (e.g., clopidogrel) where efficacy is mainly due to their active metabolite(s), concomitant use of EPIDIOLEX may decrease plasma concentration of the active metabolite(s) and may therefore decrease efficacy.
Cannabidiol Also Interacts With
- Clobazam moderate
- Tizanidine minor
- Valproate minor
- Rifampin minor
- Digoxin minor
Clopidogrel Also Interacts With
- Omeprazole moderate
- Warfarin moderate
- Esomeprazole moderate
- Rifampin moderate
- Norepinephrine moderate
Frequently Asked Questions
Can I take Cannabidiol and Clopidogrel together?
This is a minor interaction. Your doctor may need to adjust your treatment to make sure your medicine is still working correctly.
How serious is the interaction between Cannabidiol and Clopidogrel?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Cannabidiol and Clopidogrel interact?
Cannabidiol interferes with how your body activates clopidogrel, which can make the medicine less effective at preventing blood clots.
Understanding the Cannabidiol and Clopidogrel Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Cannabidiol belongs to the Cannabinoid (Anticonvulsant) class and Clopidogrel belongs to the Antiplatelet Agent class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Cannabidiol interferes with how your body activates clopidogrel, which can make the medicine less effective at preventing blood clots. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Cannabidiol has 8 total documented interactions on file in this dataset, and Clopidogrel has 19. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your doctor may need to adjust your treatment to make sure your medicine is still working correctly. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Cannabidiol or Clopidogrel based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.