What the FDA labels say about taking them together
Cannabidiol and clopidogrel
Cannabidiol's FDA label of May 29, 2026 names clopidogrel in its drug interactions section; the clopidogrel label PlainMeds reads does not name cannabidiol. The cannabidiol label: “For CYP2C19 substrates (e.g., clopidogrel) where efficacy is mainly due to their active metabolite (s), concomitant use of EPIDIOLEX may decrease plasma concentration of the active metabolite (s) and may therefore …”
Check it at the source: the cannabidiol FDA label on DailyMed (effective May 29, 2026, Jazz Pharmaceuticals, Inc.); the clopidogrel FDA label on DailyMed (effective May 30, 2025, Sanofi-Aventis U.S. LLC).
What does the cannabidiol label say about clopidogrel?
Cannabidiol label, drug interactionsFor CYP2C19 substrates (e.g., clopidogrel) where efficacy is mainly due to their active metabolite (s), concomitant use of EPIDIOLEX may decrease plasma concentration of the active metabolite (s) and may therefore decrease efficacy.
Source: FDA drug label (Epidiolex), Jazz Pharmaceuticals, Inc., effective May 29, 2026 (SPL set 8bf27097-4870-43fb-94f0-f3d0871d1eec), via openFDA; the full label on DailyMed
What does the clopidogrel label say about cannabidiol?
Clopidogrel's label (effective May 30, 2025) does not name cannabidiol in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Plavix), Sanofi-Aventis U.S. LLC, effective May 30, 2025 (SPL set de8b0b67-eb25-4684-83b5-7ad785314227), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cannabidiol | Clopidogrel | |
|---|---|---|
| Labeled for | n/a | Heart attack and coronary artery disease, Angina |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | $0.0472 per tablet 75 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once