Cannabidiol and Valproate Interaction
Drug interaction information between Cannabidiol and Valproate.
Cannabidiol and Valproate have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Cannabidiol and Valproate. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking these two medicines together can cause your liver enzymes to rise, which may indicate liver irritation.
FDA Label Information
7.3 Concomitant Use of EPIDIOLEX and Valproate Concomitant use of EPIDIOLEX and valproate increases the incidence of liver enzyme elevations [see Warnings and Precautions ( 5.1 )]. If such elevations occur, consider discontinuation or reduction of EPIDIOLEX and/or concomitant valproate.
Cannabidiol Also Interacts With
- Clobazam moderate
- Clopidogrel minor
- Tizanidine minor
- Rifampin minor
- Digoxin minor
Valproate Also Interacts With
- Ranitidine major
- Cimetidine major
- Clarithromycin moderate
- Lidocaine Topical moderate
- Risperidone moderate
Frequently Asked Questions
What SPL severity band is on file for Cannabidiol + Valproate?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Valproate has 41 labeled pairs on file vs Cannabidiol's 8. In the minor band specifically: Cannabidiol has 7 (also Clopidogrel, Tizanidine, Rifampin, Digoxin); Valproate has 36 (also Aspirin, Clonazepam, Topiramate, Amitriptyline).
What mechanism field is on file for Cannabidiol and Valproate?
Taking these two medicines together can cause your liver enzymes to rise, which may indicate liver irritation.
Valproate carries more major-labeled pairs than Cannabidiol
SPL source-record counts only. This page's band is minor · classes on file: Cannabidiol (Cannabinoid (Anticonvulsant)); Valproate (Anticonvulsant / Mood Stabilizer).
Valproate has 2 major-labeled pairs vs Cannabidiol's 0. This page itself is in the minor band, not the major band.
0 major · 1 moderate · 7 minor · 8 total
- Other minor peers for Cannabidiol
- Clopidogrel
- Tizanidine
- Rifampin
- Digoxin
2 major · 3 moderate · 36 minor · 41 total
- Other minor peers for Valproate
- Aspirin
- Clonazepam
- Topiramate
- Amitriptyline
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.