Cannabidiol and Tizanidine Interaction
Drug interaction information between Cannabidiol and Tizanidine.
Cannabidiol and Tizanidine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Cannabidiol and Tizanidine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Cannabidiol slows down the process your body uses to break down tizanidine, which can lead to higher levels of the drug in your blood.
FDA Label Information
Increases in exposure of certain CYP1A2 substrates (e.g., theophylline, tizanidine) may be observed when concomitantly used with EPIDIOLEX.
Cannabidiol Also Interacts With
- Clobazam moderate
- Clopidogrel minor
- Valproate minor
- Rifampin minor
- Digoxin minor
Tizanidine Also Interacts With
- Ciprofloxacin major
- Fluvoxamine major
- Famotidine moderate
- Acyclovir minor
- Verapamil minor
Frequently Asked Questions
What SPL severity band is on file for Cannabidiol + Tizanidine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Tizanidine has 17 labeled pairs on file vs Cannabidiol's 8. In the minor band specifically: Cannabidiol has 7 (also Clopidogrel, Valproate, Rifampin, Digoxin); Tizanidine has 14 (also Acyclovir, Verapamil, Amiodarone, Propafenone).
What mechanism field is on file for Cannabidiol and Tizanidine?
Cannabidiol slows down the process your body uses to break down tizanidine, which can lead to higher levels of the drug in your blood.
Tizanidine carries more major-labeled pairs than Cannabidiol
SPL source-record counts only. This page's band is minor · classes on file: Cannabidiol (Cannabinoid (Anticonvulsant)); Tizanidine (Central Alpha-2 Agonist (Muscle Relaxant)).
Tizanidine has 2 major-labeled pairs vs Cannabidiol's 0. This page itself is in the minor band, not the major band.
0 major · 1 moderate · 7 minor · 8 total
- Other minor peers for Cannabidiol
- Clopidogrel
- Valproate
- Rifampin
- Digoxin
2 major · 1 moderate · 14 minor · 17 total
- Other minor peers for Tizanidine
- Acyclovir
- Verapamil
- Amiodarone
- Propafenone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.