What the FDA labels say about taking them together
Cannabidiol and tizanidine
Cannabidiol's FDA label of May 29, 2026 names tizanidine in its drug interactions section; the tizanidine labels PlainMeds reads (3) do not name cannabidiol. The cannabidiol label: “Increases in exposure of certain CYP1A2 substrates may be observed when concomitantly used with EPIDIOLEX.”
Check it at the source: the cannabidiol FDA label on DailyMed (effective May 29, 2026, Jazz Pharmaceuticals, Inc.); the tizanidine FDA label on DailyMed (effective January 2, 2026, Legacy Pharma USA, Inc.).
What does the cannabidiol label say about tizanidine?
Cannabidiol label, drug interactionsIncreases in exposure of certain CYP1A2 substrates (e.g., theophylline, tizanidine) may be observed when concomitantly used with EPIDIOLEX.
Source: FDA drug label (Epidiolex), Jazz Pharmaceuticals, Inc., effective May 29, 2026 (SPL set 8bf27097-4870-43fb-94f0-f3d0871d1eec), via openFDA; the full label on DailyMed
What does the tizanidine label say about cannabidiol?
Tizanidine's label (effective January 2, 2026) and its 2 other brand-application labels do not name cannabidiol in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Zanaflex), Legacy Pharma USA, Inc., effective January 2, 2026 (SPL set 60c27d35-7349-4fc6-86ad-70fffdbe3e08), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cannabidiol | Tizanidine | |
|---|---|---|
| Labeled for | n/a | Muscle spasms and spasticity |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $0.0331 per tablet 4 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once