Meperidine and Gabapentin Interaction
Drug interaction information between Meperidine and Gabapentin.
Meperidine and Gabapentin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Meperidine and Gabapentin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs slow down the central nervous system. This can lead to increased sleepiness, dizziness, or breathing difficulties.
FDA Label Information
Examples: Benzodiazepines and other sedatives/hypnotics, anxiolytics, tranquilizers, muscle relaxants, general anesthetics, antipsychotics, gabapentinoids (gabapentin or pregabalin), other opioids, alcohol.
Meperidine Also Interacts With
- Safinamide major
- Rasagiline moderate
- Tranylcypromine moderate
- Trazodone minor
- Tramadol minor
Gabapentin Also Interacts With
- Acetaminophen/Oxycodone moderate
- Oxycodone minor
- Estradiol minor
- Naproxen minor
- Norethindrone minor
Frequently Asked Questions
What SPL severity band is on file for Meperidine + Gabapentin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Meperidine has 31 labeled pairs on file vs Gabapentin's 19. In the minor band specifically: Meperidine has 28 (also Trazodone, Tramadol, Cyclobenzaprine, Pregabalin); Gabapentin has 18 (also Oxycodone, Estradiol, Naproxen, Norethindrone).
What mechanism field is on file for Meperidine and Gabapentin?
Both drugs slow down the central nervous system. This can lead to increased sleepiness, dizziness, or breathing difficulties.
Meperidine carries more major-labeled pairs than Gabapentin
SPL source-record counts only. This page's band is minor · classes on file: Meperidine (Opioid Analgesic); Gabapentin (Anticonvulsant / Nerve Pain Agent).
Meperidine has 1 major-labeled pair vs Gabapentin's 0. This page itself is in the minor band, not the major band.
1 major · 2 moderate · 28 minor · 31 total
- Other minor peers for Meperidine
- Trazodone
- Tramadol
- Cyclobenzaprine
- Pregabalin
0 major · 1 moderate · 18 minor · 19 total
- Other minor peers for Gabapentin
- Oxycodone
- Estradiol
- Naproxen
- Norethindrone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.