Meperidine and Safinamide Interaction
Drug interaction information between Meperidine and Safinamide.
Meperidine and Safinamide have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Meperidine and Safinamide. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This combination can cause a severe, life-threatening reaction by interfering with how the brain handles certain chemicals.
FDA Label Information
7.2 Opioid Drugs Because serious, sometimes fatal reactions have been precipitated with concomitant use of opioid drugs (e.g., meperidine and its derivatives, methadone, propoxyphene, or tramadol) and MAOIs, including selective MAO-B inhibitors, concomitant use of these drugs is contraindicated [see Warnings and Precautions (5.2) ] .
Meperidine Also Interacts With
- Rasagiline moderate
- Tranylcypromine moderate
- Gabapentin minor
- Trazodone minor
- Tramadol minor
Safinamide Also Interacts With
- Tramadol major
- Methylphenidate major
- Linezolid major
- Methadone major
- Dextromethorphan major
Frequently Asked Questions
What SPL severity band is on file for Meperidine + Safinamide?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Meperidine has 31 labeled pairs on file vs Safinamide's 10. In the major band specifically: Meperidine has 1; Safinamide has 6 (also Tramadol, Methylphenidate, Linezolid, Methadone).
What mechanism field is on file for Meperidine and Safinamide?
This combination can cause a severe, life-threatening reaction by interfering with how the brain handles certain chemicals.
Safinamide carries more major-labeled pairs than Meperidine
SPL source-record counts only. This page's band is major · classes on file: Meperidine (Opioid Analgesic); Safinamide (MAO-B Inhibitor).
Safinamide has 6 major-labeled pairs vs Meperidine's 1.
1 major · 2 moderate · 28 minor · 31 total
Meperidine has no other major-band peer in this dataset besides Safinamide.
6 major · 0 moderate · 4 minor · 10 total
- Other major peers for Safinamide
- Tramadol
- Methylphenidate
- Linezolid
- Methadone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.