Meperidine and Tranylcypromine Interaction
Drug interaction information between Meperidine and Tranylcypromine.
Meperidine and Tranylcypromine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Meperidine and Tranylcypromine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This combination can cause a life-threatening reaction involving very high blood pressure or too much serotonin in the brain. The drugs prevent your body from properly breaking down these powerful chemicals.
FDA Label Information
Product Clinical Comment on Concomitant Use [See Contraindications (4.1)] ; Predominant Effect/Risk [Hypertensive Reaction (HR) [See Warnings and Precautions (5.3)] ; or Serotonin Syndrome (SS) [See Warnings and Precautions (5.7)] ] Altretamine Use with caution If not otherwise specified in this table, consider avoiding concomitant use (see also information on medication-free intervals , use agent at the lowest appropriate dose, monitor for effects of the interaction, advise the patient to report potential effects, and be prepared to discontinue the agent and treat effects of the...
Meperidine Also Interacts With
- Safinamide major
- Rasagiline moderate
- Gabapentin minor
- Trazodone minor
- Tramadol minor
Tranylcypromine Also Interacts With
- Bupropion major
- Linezolid major
- Vilazodone major
- Epinephrine major
- Norepinephrine major
Frequently Asked Questions
What SPL severity band is on file for Meperidine + Tranylcypromine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Tranylcypromine has 42 labeled pairs on file vs Meperidine's 31. In the moderate band specifically: Meperidine has 2 (also Rasagiline); Tranylcypromine has 23 (also Buspirone, Cyclobenzaprine, Carbamazepine, Lithium).
What mechanism field is on file for Meperidine and Tranylcypromine?
This combination can cause a life-threatening reaction involving very high blood pressure or too much serotonin in the brain. The drugs prevent your body from properly breaking down these powerful chemicals.
Tranylcypromine carries more major-labeled pairs than Meperidine
SPL source-record counts only. This page's band is moderate · classes on file: Meperidine (Opioid Analgesic); Tranylcypromine (Monoamine Oxidase Inhibitor (MAOI)).
Tranylcypromine has 7 major-labeled pairs vs Meperidine's 1. This page itself is in the moderate band, not the major band.
1 major · 2 moderate · 28 minor · 31 total
- Other moderate peers for Meperidine
- Rasagiline
7 major · 23 moderate · 12 minor · 42 total
- Other moderate peers for Tranylcypromine
- Buspirone
- Cyclobenzaprine
- Carbamazepine
- Lithium
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.