Meperidine and Trazodone Interaction
Drug interaction information between Meperidine and Trazodone.
Meperidine and Trazodone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Meperidine and Trazodone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs increase the level of a brain chemical called serotonin. Too much serotonin can cause a serious reaction called serotonin syndrome.
FDA Label Information
Examples: Selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), triptans, 5-HT3 receptor antagonists, drugs that effect the serotonin neurotransmitter system (e.g., mirtazapine, trazodone, tramadol), certain muscle relaxants (i.e., cyclobenzaprine, metaxalone), monoamine oxidase inhibitors (MAOIs) (those intended to treat psychiatric disorders and also others, such as linezolid and intravenous methylene blue).
Meperidine Also Interacts With
- Safinamide major
- Rasagiline moderate
- Tranylcypromine moderate
- Gabapentin minor
- Tramadol minor
Trazodone Also Interacts With
- Linezolid major
- Aspirin moderate
- Phenelzine moderate
- Tranylcypromine moderate
- Selegiline moderate
Frequently Asked Questions
What SPL severity band is on file for Meperidine + Trazodone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Trazodone has 40 labeled pairs on file vs Meperidine's 31. In the minor band specifically: Meperidine has 28 (also Gabapentin, Tramadol, Cyclobenzaprine, Pregabalin); Trazodone has 35 (also Tramadol, Buspirone, Clopidogrel, Rivaroxaban).
What mechanism field is on file for Meperidine and Trazodone?
Both drugs increase the level of a brain chemical called serotonin. Too much serotonin can cause a serious reaction called serotonin syndrome.
Trazodone's labeled portfolio outnumbers Meperidine
SPL source-record counts only. This page's band is minor · classes on file: Meperidine (Opioid Analgesic); Trazodone (Serotonin Antagonist and Reuptake Inhibitor (SARI)).
1 major · 2 moderate · 28 minor · 31 total
- Other minor peers for Meperidine
- Gabapentin
- Tramadol
- Cyclobenzaprine
- Pregabalin
1 major · 4 moderate · 35 minor · 40 total
- Other minor peers for Trazodone
- Tramadol
- Buspirone
- Clopidogrel
- Rivaroxaban
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.