Meperidine and Rasagiline Interaction
Drug interaction information between Meperidine and Rasagiline.
Meperidine and Rasagiline have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Meperidine and Rasagiline. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Combining these medications can cause a life-threatening reaction called serotonin syndrome, where a brain chemical reaches dangerously high levels. This can lead to serious or even fatal health problems.
FDA Label Information
7 DRUG INTERACTIONS Meperidine: Risk of serotonin syndrome (4, 7.1) Dextromethorphan: Risk of psychosis or bizarre behavior (4, 7.2) MAO inhibitors: Risk of non-selective MAO inhibition and hypertensive crisis (4, 7.3) 7.1 Meperidine Serious, sometimes fatal reactions have been precipitated with concomitant use of meperidine (e.g., Demerol and other tradenames) and MAO inhibitors including selective MAO-B inhibitors [see Contraindications (4)] .
Meperidine Also Interacts With
- Safinamide major
- Tranylcypromine moderate
- Gabapentin minor
- Trazodone minor
- Tramadol minor
Rasagiline Also Interacts With
- Dextromethorphan moderate
- Tranylcypromine moderate
- Ciprofloxacin minor
- Dopamine minor
- Norepinephrine minor
Frequently Asked Questions
What SPL severity band is on file for Meperidine + Rasagiline?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Meperidine has 31 labeled pairs on file vs Rasagiline's 7. In the moderate band specifically: Meperidine has 2 (also Tranylcypromine); Rasagiline has 3 (also Dextromethorphan, Tranylcypromine).
What mechanism field is on file for Meperidine and Rasagiline?
Combining these medications can cause a life-threatening reaction called serotonin syndrome, where a brain chemical reaches dangerously high levels. This can lead to serious or even fatal health problems.
Meperidine carries more major-labeled pairs than Rasagiline
SPL source-record counts only. This page's band is moderate · classes on file: Meperidine (Opioid Analgesic); Rasagiline (MAO-B Inhibitor).
Meperidine has 1 major-labeled pair vs Rasagiline's 0. This page itself is in the moderate band, not the major band.
1 major · 2 moderate · 28 minor · 31 total
- Other moderate peers for Meperidine
- Tranylcypromine
0 major · 3 moderate · 4 minor · 7 total
- Other moderate peers for Rasagiline
- Dextromethorphan
- Tranylcypromine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.