Chloroquine and Methylprednisolone Interaction
Drug interaction information between Chloroquine and Methylprednisolone.
Chloroquine and Methylprednisolone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Chloroquine and Methylprednisolone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Chloroquine is known to cause a blood condition called methemoglobinemia, which makes it harder for your blood to carry oxygen. Taking it with other medications may increase the risk of this blood disorder.
FDA Label Information
Examples of Drugs Associated with Methemoglobinemia: Class Examples Nitrates/Nitrites nitric oxide, nitroglycerin, nitroprusside, nitrous oxide Local anesthetics articaine, benzocaine, bupivacaine, lidocaine, mepivacaine, prilocaine, procaine, ropivacaine, tetracaine Antineoplastic agents cyclophosphamide, flutamide, hydroxyurea, isofamide, rasburicase Antibiotics dapsone, nitrofurantoin, para-aminosalicylic acid, sulfonamides Antimalarials chloroquine, primaquine Anticonvulsants phenobarbital, phenytoin, sodium valproate Other drugs acetaminophen, metoclopramide, quinine, sulfasalazine...
Chloroquine Also Interacts With
- Dapsone Topical moderate
- Hydroxychloroquine moderate
- Lidocaine Topical moderate
- Remdesivir moderate
Methylprednisolone Also Interacts With
- Theophylline major
- Aspirin moderate
- Ketoconazole moderate
- Aprepitant moderate
- Clarithromycin moderate
Frequently Asked Questions
What SPL severity band is on file for Chloroquine + Methylprednisolone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Methylprednisolone has 29 labeled pairs on file vs Chloroquine's 5. In the minor band specifically: Chloroquine has 1; Methylprednisolone has 22 (also Acetaminophen, Warfarin, Nitrofurantoin, Valproate).
What mechanism field is on file for Chloroquine and Methylprednisolone?
Chloroquine is known to cause a blood condition called methemoglobinemia, which makes it harder for your blood to carry oxygen. Taking it with other medications may increase the risk of this blood disorder.
Methylprednisolone carries more major-labeled pairs than Chloroquine
SPL source-record counts only. This page's band is minor · classes on file: Chloroquine (Antimalarial); Methylprednisolone (Corticosteroid).
Methylprednisolone has 1 major-labeled pair vs Chloroquine's 0. This page itself is in the minor band, not the major band.
0 major · 4 moderate · 1 minor · 5 total
Chloroquine has no other minor-band peer in this dataset besides Methylprednisolone.
1 major · 6 moderate · 22 minor · 29 total
- Other minor peers for Methylprednisolone
- Acetaminophen
- Warfarin
- Nitrofurantoin
- Valproate
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.