Chloroquine and Lidocaine Topical Interaction
Drug interaction information between Chloroquine and Lidocaine Topical.
Chloroquine and Lidocaine Topical have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Chloroquine and Lidocaine Topical. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs can interfere with how your blood carries oxygen, which can lead to a dangerous health issue. Combining them makes this problem more likely to happen.
FDA Label Information
Drugs That May Cause Methemoglobinemia When Used with LIDODERM Patients who are administered local anesthetics are at increased risk of developing methemoglobinemia when concurrently exposed to the following drugs, which could include other local anesthetics: Examples of Drugs Associated with Methemoglobinemia : Class Examples Nitrates/Nitrites nitric oxide, nitroglycerin, nitroprusside, nitrous oxide Local anesthetics articaine, benzocaine, bupivacaine, lidocaine, mepivacaine, prilocaine, procaine, ropivacaine, tetracaine Antineoplastic agents cyclophosphamide, flutamide, hydroxyurea,...
Chloroquine Also Interacts With
- Dapsone Topical moderate
- Hydroxychloroquine moderate
- Remdesivir moderate
- Methylprednisolone minor
Lidocaine Topical Also Interacts With
- Acetaminophen moderate
- Nitrofurantoin moderate
- Valproate moderate
- Mexiletine moderate
- Nitroglycerin moderate
Frequently Asked Questions
What SPL severity band is on file for Chloroquine + Lidocaine Topical?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Lidocaine Topical has 10 labeled pairs on file vs Chloroquine's 5. In the moderate band specifically: Chloroquine has 4 (also Dapsone Topical, Hydroxychloroquine, Remdesivir); Lidocaine Topical has 10 (also Acetaminophen, Nitrofurantoin, Valproate, Mexiletine).
What mechanism field is on file for Chloroquine and Lidocaine Topical?
Both drugs can interfere with how your blood carries oxygen, which can lead to a dangerous health issue. Combining them makes this problem more likely to happen.
Lidocaine Topical's labeled portfolio outnumbers Chloroquine
SPL source-record counts only. This page's band is moderate · classes on file: Chloroquine (Antimalarial); Lidocaine Topical (Topical Anesthetic).
0 major · 4 moderate · 1 minor · 5 total
- Other moderate peers for Chloroquine
- Dapsone Topical
- Hydroxychloroquine
- Remdesivir
0 major · 10 moderate · 0 minor · 10 total
- Other moderate peers for Lidocaine Topical
- Acetaminophen
- Nitrofurantoin
- Valproate
- Mexiletine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.