cannabidiol vs digoxin
Side-by-side comparison of cannabidiol and digoxin. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Increases in exposure of other orally administered P‑gp substrates (e.g., sirolimus, tacrolimus, digoxin) may be observed when concomitantly used with EPIDIOLEX.
Recommendation: Your doctor should monitor your blood levels of digoxin closely to make sure they stay in a safe range.
Epidiolex
Lanoxin
Epidiolex is a medicine that contains cannabidiol. It is used to treat seizures in people with certain conditions.
Digoxin (Lanoxin) is a medicine that helps your heart pump better. It is used to treat heart failure and control irregular heartbeats.
Epidiolex is used to treat seizures linked to Lennox-Gastaut syndrome (LGS), Dravet syndrome (DS), or tuberous sclerosis complex (TSC). It is for patients who are at least 1 year old. These conditions can cause seizures that are hard to control.
Digoxin is used to treat mild to moderate heart failure in adults. It helps the heart pump more blood with each beat. Digoxin is also used in children with heart failure to help their heart work better. In adults, it can control a fast and irregular heartbeat called atrial fibrillation.
Epidiolex contains cannabidiol, which is a substance that may affect how the brain works. It is thought to reduce seizures by acting on certain brain chemicals. The exact way it works is not fully understood.
Digoxin belongs to a class of drugs called cardiac glycosides. It works by making the heart muscle contract more strongly. It also slows down the electrical signals in the heart, which can help control irregular heartbeats.
- • Feeling sleepy
- • Decreased appetite
- • Diarrhea
- • Changes in liver blood tests
- • Feeling tired or weak
- • Nausea
- • Vomiting
- • Diarrhea
- • Dizziness
- • Headache
- Seizure 5,791
- Hospital stay 2,073
- Diarrhea 1,695
- Sleepiness 1,242
- Death 1,204
- Shortness of breath 6,062
- Feeling sick to your stomach 4,747
- Feeling lightheaded or unsteady 4,442
- Feeling very tired 4,174
- Irregular heartbeat 3,972
Epidiolex can cause liver problems. Your doctor will check your liver before you start and during treatment. Tell your doctor right away if you feel very tired, have yellowing of the skin or eyes, dark urine, or loss of appetite. Epidiolex may also cause sleepiness or suicidal thoughts. Tell your doctor if you have any changes in mood or behavior.
Digoxin can cause serious side effects, including dangerous heart rhythms. You are at higher risk if you have certain heart conditions or kidney problems. Tell your doctor right away if you have nausea, vomiting, vision changes, or an irregular heartbeat.
Tell your doctor if you are pregnant or plan to become pregnant. Epidiolex may harm your unborn baby. There are pregnancy programs to monitor outcomes, so talk to your doctor about enrolling. It is not known if Epidiolex passes into breast milk, so talk to your doctor about the best way to feed your baby if you are taking this medicine.
It is not known if digoxin can harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. The medicine passes into breast milk, but it is unlikely to harm the baby.
How to Read This cannabidiol vs digoxin Comparison
cannabidiol is classified in the Cannabinoid (Anticonvulsant) drug class, while digoxin sits within the Cardiac Glycoside class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, cannabidiol has 12,005 submissions while digoxin has 23,397. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to cannabidiol can block a protein that helps remove digoxin from your body, causing the drug to build up to higher levels.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between cannabidiol and digoxin - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.