Budesonide/Formoterol and Itraconazole Interaction
Drug interaction information between Budesonide/Formoterol and Itraconazole.
Budesonide/Formoterol and Itraconazole have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Budesonide/Formoterol and Itraconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Itraconazole blocks the enzyme that breaks down the steroid part of this inhaler. This can lead to higher levels of the medicine in your body than intended.
FDA Label Information
Caution should be exercised when considering the coadministration of SYMBICORT with long-term ketoconazole and other known strong CYP3A4 inhibitors (e.g., ritonavir, atazanavir, clarithromycin, indinavir, itraconazole, nefazodone, nelfinavir, saquinavir, telithromycin) [see Warnings and Precautions (5.9) ] .
Budesonide/Formoterol Also Interacts With
- Ketoconazole moderate
- Clarithromycin moderate
- Formoterol moderate
- Budesonide minor
Itraconazole Also Interacts With
- Isavuconazonium major
- Lurasidone major
- Pimozide major
- Methadone major
- Midazolam major
Frequently Asked Questions
What SPL severity band is on file for Budesonide/Formoterol + Itraconazole?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Itraconazole has 116 labeled pairs on file vs Budesonide/Formoterol's 5. In the moderate band specifically: Budesonide/Formoterol has 4 (also Ketoconazole, Clarithromycin, Formoterol); Itraconazole has 20 (also Tamsulosin, Rivaroxaban, Tenofovir Disoproxil, Glecaprevir/Pibrentasvir).
What mechanism field is on file for Budesonide/Formoterol and Itraconazole?
Itraconazole blocks the enzyme that breaks down the steroid part of this inhaler. This can lead to higher levels of the medicine in your body than intended.
Itraconazole carries more major-labeled pairs than Budesonide/Formoterol
SPL source-record counts only. This page's band is moderate · classes on file: Budesonide/Formoterol (Corticosteroid / Long-Acting Beta-2 Agonist Combination); Itraconazole (Azole Antifungal).
Itraconazole has 19 major-labeled pairs vs Budesonide/Formoterol's 0. This page itself is in the moderate band, not the major band.
0 major · 4 moderate · 1 minor · 5 total
- Other moderate peers for Budesonide/Formoterol
- Ketoconazole
- Clarithromycin
- Formoterol
19 major · 20 moderate · 77 minor · 116 total
- Other moderate peers for Itraconazole
- Tamsulosin
- Rivaroxaban
- Tenofovir Disoproxil
- Glecaprevir/Pibrentasvir
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.