Budesonide/Formoterol and Budesonide Interaction
Drug interaction information between Budesonide/Formoterol and Budesonide.
Budesonide/Formoterol and Budesonide have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Budesonide/Formoterol and Budesonide. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Certain medications can slow down how your body breaks down budesonide. This causes the drug to stay in your system longer and reach higher levels.
FDA Label Information
(7.4) 7.1 Inhibitors of Cytochrome P4503A4 The main route of metabolism of corticosteroids, including budesonide, a component of SYMBICORT, is via cytochrome P450 (CYP) isoenzyme 3A4 (CYP3A4). After oral administration of ketoconazole, a strong inhibitor of CYP3A4, the mean plasma concentration of orally administered budesonide increased. Concomitant administration of CYP3A4 may inhibit the metabolism of, and increase the systemic exposure to, budesonide.
Budesonide/Formoterol Also Interacts With
- Ketoconazole moderate
- Clarithromycin moderate
- Itraconazole moderate
- Formoterol moderate
Budesonide Also Interacts With
- Darunavir moderate
- Nirmatrelvir/Ritonavir moderate
- Itraconazole minor
Frequently Asked Questions
What SPL severity band is on file for Budesonide/Formoterol + Budesonide?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Budesonide/Formoterol has 5 labeled pairs on file vs Budesonide's 4. In the minor band specifically: Budesonide/Formoterol has 1; Budesonide has 2 (also Itraconazole).
What mechanism field is on file for Budesonide/Formoterol and Budesonide?
Certain medications can slow down how your body breaks down budesonide. This causes the drug to stay in your system longer and reach higher levels.
Budesonide/Formoterol's labeled portfolio outnumbers Budesonide
SPL source-record counts only. This page's band is minor · classes on file: Budesonide/Formoterol (Corticosteroid / Long-Acting Beta-2 Agonist Combination); Budesonide (Corticosteroid).
0 major · 4 moderate · 1 minor · 5 total
Budesonide/Formoterol has no other minor-band peer in this dataset besides Budesonide.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.