brexpiprazole vs bupropion
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Side-by-side comparison of brexpiprazole and bupropion. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Additionally, no dosage adjustment for substrates of CYP2D6 (e.g., dextromethorphan), CYP3A4 (e.g., lovastatin), CYP2B6 (e.g., bupropion), BCRP (e.g., rosuvastatin), or P-gp (e.g., fexofenadine) is required when administered concomitantly with REXULTI.
Rexulti
Wellbutrin, Zyban
Rexulti is a medication used to treat certain mental health conditions. It can help with depression, schizophrenia, and agitation related to Alzheimer's disease.
Bupropion is a medicine used to treat depression and prevent seasonal affective disorder (SAD). It can help improve your mood and energy levels.
Rexulti can be used with antidepressants to treat major depressive disorder in adults. It can also treat schizophrenia in adults and children 13 years and older. Additionally, Rexulti can help manage agitation in people with dementia due to Alzheimer's disease. Rexulti should not be used as needed for agitation related to dementia.
Bupropion is used to treat major depressive disorder (MDD), which can cause you to feel sad, lose interest in activities, and have trouble sleeping or eating. It is also used to prevent seasonal affective disorder (SAD), a type of depression that occurs during the fall and winter.
Rexulti affects the balance of certain natural chemicals in the brain. These chemicals, called neurotransmitters, include dopamine and serotonin. By affecting these chemicals, Rexulti can help improve mood, thinking, and behavior.
Bupropion works by affecting certain chemicals in the brain called norepinephrine and dopamine. It helps to increase the levels of these chemicals, which can improve mood and reduce symptoms of depression.
- • Weight gain
- • Feeling sleepy
- • Restlessness or feeling like you need to move
- • Dry mouth
- • Nausea
- • Trouble sleeping
- • Dizziness
- • Sore throat
- Weight Increased 1,673
- Akathisia 854
- Tremor 630
- Anxiety 591
- Tardive Dyskinesia 590
- Completed Suicide 4,408
- Toxicity To Various Agents 3,113
- Fatigue 2,665
- Nausea 2,309
- Headache 2,218
Elderly patients with dementia-related psychosis who are treated with antipsychotic drugs have an increased risk of death. Rexulti is not approved to treat dementia-related psychosis unless it is related to agitation from Alzheimer's disease. Antidepressants may increase the risk of suicidal thoughts and behaviors in young adults and children. Tell your doctor right away if you have thoughts of harming yourself.
Antidepressants may increase the risk of suicidal thoughts and behaviors in children, teenagers, and young adults. Watch closely for worsening depression or suicidal thoughts. Tell your doctor right away if you notice any changes in mood or behavior.
Tell your doctor if you are pregnant or plan to become pregnant. Babies born to mothers who take Rexulti in the last 3 months of pregnancy may have withdrawal symptoms or other problems after birth. There is a pregnancy registry to monitor outcomes in women exposed to Rexulti during pregnancy. You can contact the registry at 1-866-961-2388.
Talk to your doctor if you are pregnant or plan to become pregnant. It is important to consider the risks of untreated depression during pregnancy. There is a pregnancy registry to monitor outcomes in women exposed to antidepressants during pregnancy. You can register by calling 1-844-405-6185.
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How to Read This brexpiprazole vs bupropion Comparison
brexpiprazole is classified in the Atypical Antipsychotic drug class, while bupropion sits within the Norepinephrine-Dopamine Reuptake Inhibitor (NDRI) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, brexpiprazole has 4,338 submissions while bupropion has 14,713. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to brexpiprazole does not change how the liver enzymes break down bupropion in the body.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for brexpiprazole or bupropion.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.