Bempedoic Acid/Ezetimibe and Simvastatin Interaction
Drug interaction information between Bempedoic Acid/Ezetimibe and Simvastatin.
Bempedoic Acid/Ezetimibe and Simvastatin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Bempedoic Acid/Ezetimibe and Simvastatin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking these together can cause simvastatin levels to rise in your body, which may lead to muscle pain or weakness.
FDA Label Information
Clinically Important Drug Interactions with NEXLIZET Simvastatin Clinical Impact: Concomitant use of NEXLIZET with simvastatin causes an increase in simvastatin concentration and may increase the risk of simvastatin-related myopathy [see Clinical Pharmacology (12.3) ] . Intervention: Avoid concomitant use of NEXLIZET with simvastatin greater than 20 mg. Simvastatin: Avoid concomitant use of NEXLIZET with simvastatin greater than 20 mg.
Bempedoic Acid/Ezetimibe Also Interacts With
- Pravastatin moderate
- Fenofibrate moderate
- Bempedoic Acid moderate
- Ezetimibe minor
- Cyclosporine minor
Simvastatin Also Interacts With
- Diltiazem major
- Verapamil major
- Cyclosporine major
- Amiodarone major
- Dronedarone major
Frequently Asked Questions
What SPL severity band is on file for Bempedoic Acid/Ezetimibe + Simvastatin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Simvastatin has 41 labeled pairs on file vs Bempedoic Acid/Ezetimibe's 7. In the moderate band specifically: Bempedoic Acid/Ezetimibe has 4 (also Pravastatin, Fenofibrate, Bempedoic Acid); Simvastatin has 9 (also Ezetimibe, Daptomycin, Colchicine, Niacin).
What mechanism field is on file for Bempedoic Acid/Ezetimibe and Simvastatin?
Taking these together can cause simvastatin levels to rise in your body, which may lead to muscle pain or weakness.
Simvastatin carries more major-labeled pairs than Bempedoic Acid/Ezetimibe
SPL source-record counts only. This page's band is moderate · classes on file: Bempedoic Acid/Ezetimibe (ACL Inhibitor / Cholesterol Absorption Inhibitor); Simvastatin (HMG-CoA Reductase Inhibitor (Statin)).
Simvastatin has 11 major-labeled pairs vs Bempedoic Acid/Ezetimibe's 0. This page itself is in the moderate band, not the major band.
0 major · 4 moderate · 3 minor · 7 total
- Other moderate peers for Bempedoic Acid/Ezetimibe
- Pravastatin
- Fenofibrate
- Bempedoic Acid
11 major · 9 moderate · 21 minor · 41 total
- Other moderate peers for Simvastatin
- Ezetimibe
- Daptomycin
- Colchicine
- Niacin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.