Bempedoic Acid/Ezetimibe and Pravastatin Interaction
Drug interaction information between Bempedoic Acid/Ezetimibe and Pravastatin.
Bempedoic Acid/Ezetimibe and Pravastatin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Bempedoic Acid/Ezetimibe and Pravastatin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This medicine can raise the levels of pravastatin in your blood, which may lead to muscle pain or weakness.
FDA Label Information
Pravastatin Clinical Impact: Concomitant use of NEXLIZET with pravastatin causes an increase in pravastatin concentration and may increase the risk of pravastatin-related myopathy [see Clinical Pharmacology (12.3) ] . Intervention: Avoid concomitant use of NEXLIZET with pravastatin greater than 40 mg. ( 7 ) Pravastatin: Avoid concomitant use of NEXLIZET with pravastatin greater than 40 mg.
Bempedoic Acid/Ezetimibe Also Interacts With
- Simvastatin moderate
- Fenofibrate moderate
- Bempedoic Acid moderate
- Ezetimibe minor
- Cyclosporine minor
Pravastatin Also Interacts With
- Cyclosporine moderate
- Erythromycin moderate
- Clarithromycin moderate
- Colchicine moderate
- Gemfibrozil moderate
Frequently Asked Questions
What SPL severity band is on file for Bempedoic Acid/Ezetimibe + Pravastatin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Pravastatin has 16 labeled pairs on file vs Bempedoic Acid/Ezetimibe's 7. In the moderate band specifically: Bempedoic Acid/Ezetimibe has 4 (also Simvastatin, Fenofibrate, Bempedoic Acid); Pravastatin has 9 (also Cyclosporine, Erythromycin, Clarithromycin, Colchicine).
What mechanism field is on file for Bempedoic Acid/Ezetimibe and Pravastatin?
This medicine can raise the levels of pravastatin in your blood, which may lead to muscle pain or weakness.
Pravastatin's labeled portfolio outnumbers Bempedoic Acid/Ezetimibe
SPL source-record counts only. This page's band is moderate · classes on file: Bempedoic Acid/Ezetimibe (ACL Inhibitor / Cholesterol Absorption Inhibitor); Pravastatin (HMG-CoA Reductase Inhibitor (Statin)).
0 major · 4 moderate · 3 minor · 7 total
- Other moderate peers for Bempedoic Acid/Ezetimibe
- Simvastatin
- Fenofibrate
- Bempedoic Acid
0 major · 9 moderate · 7 minor · 16 total
- Other moderate peers for Pravastatin
- Cyclosporine
- Erythromycin
- Clarithromycin
- Colchicine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.