Bempedoic Acid/Ezetimibe and Bempedoic Acid Interaction
Drug interaction information between Bempedoic Acid/Ezetimibe and Bempedoic Acid.
Bempedoic Acid/Ezetimibe and Bempedoic Acid have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Bempedoic Acid/Ezetimibe and Bempedoic Acid. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This combination can cause simvastatin levels to build up in your body, which increases the risk of muscle damage.
FDA Label Information
7 DRUG INTERACTIONS No specific pharmacokinetic drug interaction studies with NEXLIZET have been conducted. Table 4 lists drug interactions with NEXLIZET that have been identified in studies with bempedoic acid or ezetimibe. Clinically Important Drug Interactions with NEXLIZET Simvastatin Clinical Impact: Concomitant use of NEXLIZET with simvastatin causes an increase in simvastatin concentration and may increase the risk of simvastatin-related myopathy [see Clinical Pharmacology (12.3) ] .
Bempedoic Acid/Ezetimibe Also Interacts With
- Simvastatin moderate
- Pravastatin moderate
- Fenofibrate moderate
- Ezetimibe minor
- Cyclosporine minor
Bempedoic Acid Also Interacts With
- Simvastatin moderate
- Pravastatin moderate
- Fenofibrate moderate
- Ezetimibe minor
- Cyclosporine minor
Frequently Asked Questions
What SPL severity band is on file for Bempedoic Acid/Ezetimibe + Bempedoic Acid?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
How many labeled pairs sit in each drug's moderate band?
Bempedoic Acid/Ezetimibe and Bempedoic Acid tie at 7 labeled pairs each. moderate-band counts: Bempedoic Acid/Ezetimibe 4 alongside Simvastatin, Pravastatin, Fenofibrate; Bempedoic Acid 4 alongside Simvastatin, Pravastatin, Fenofibrate.
What mechanism field is on file for Bempedoic Acid/Ezetimibe and Bempedoic Acid?
This combination can cause simvastatin levels to build up in your body, which increases the risk of muscle damage.
Bempedoic Acid/Ezetimibe and Bempedoic Acid · moderate-band peers
SPL source-record counts only. This page's band is moderate · classes on file: Bempedoic Acid/Ezetimibe (ACL Inhibitor / Cholesterol Absorption Inhibitor); Bempedoic Acid (ACL Inhibitor).
0 major · 4 moderate · 3 minor · 7 total
- Other moderate peers for Bempedoic Acid/Ezetimibe
- Simvastatin
- Pravastatin
- Fenofibrate
0 major · 4 moderate · 3 minor · 7 total
- Other moderate peers for Bempedoic Acid
- Simvastatin
- Pravastatin
- Fenofibrate
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.