Aspirin and Alendronate Interaction
Drug interaction information between Aspirin and Alendronate.
Aspirin and Alendronate have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Aspirin and Alendronate. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these medicines can be hard on your stomach and esophagus. Using them together increases the chance of developing irritation or ulcers in your digestive system.
FDA Label Information
( 7.1 ) Use caution when co-prescribing aspirin/nonsteroidal anti- inflammatory drugs that may worsen gastrointestinal irritation. 7.2 Aspirin In clinical studies, the incidence of upper gastrointestinal adverse events was increased in patients receiving concomitant therapy with daily doses of alendronate sodium greater than 10 mg and aspirin-containing products.
Aspirin Also Interacts With
- Atenolol major
- Fluoxetine major
- Ibandronate major
- Apixaban moderate
- Desvenlafaxine moderate
Frequently Asked Questions
What SPL severity band is on file for Aspirin + Alendronate?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Aspirin has 47 labeled pairs on file vs Alendronate's 2. In the moderate band specifically: Aspirin has 12 (also Apixaban, Desvenlafaxine, Dexamethasone, Duloxetine); Alendronate has 1.
What mechanism field is on file for Aspirin and Alendronate?
Both of these medicines can be hard on your stomach and esophagus. Using them together increases the chance of developing irritation or ulcers in your digestive system.
Aspirin carries more major-labeled pairs than Alendronate
SPL source-record counts only. This page's band is moderate · classes on file: Aspirin (Antiplatelet / NSAID); Alendronate (Bisphosphonate).
Aspirin has 3 major-labeled pairs vs Alendronate's 0. This page itself is in the moderate band, not the major band.
3 major · 12 moderate · 32 minor · 47 total
- Other moderate peers for Aspirin
- Apixaban
- Desvenlafaxine
- Dexamethasone
- Duloxetine
0 major · 1 moderate · 1 minor · 2 total
Alendronate has no other moderate-band peer in this dataset besides Aspirin.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.