Aspirin and Apixaban Interaction
Drug interaction information between Aspirin and Apixaban.
Aspirin and Apixaban have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Aspirin and Apixaban. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Aspirin and apixaban both thin the blood, and taking them together can nearly double your risk of having a bleeding event. This happens because both drugs make it harder for your blood to clot.
FDA Label Information
7.3 Anticoagulants and Antiplatelet Agents Coadministration of antiplatelet agents, fibrinolytics, heparin, aspirin, and chronic NSAID use increases the risk of bleeding. APPRAISE-2, a placebo-controlled clinical trial of apixaban in high-risk, post-acute coronary syndrome patients treated with aspirin or the combination of aspirin and clopidogrel, was terminated early due to a higher rate of bleeding with apixaban compared to placebo. In ARISTOTLE, concomitant use of aspirin increased the bleeding risk on apixaban from 1.8% per year to 3.4% per year and concomitant use of aspirin and...
Aspirin Also Interacts With
- Atenolol major
- Fluoxetine major
- Ibandronate major
- Alendronate moderate
- Desvenlafaxine moderate
Apixaban Also Interacts With
- Clopidogrel moderate
- Warfarin moderate
- Carbamazepine moderate
- Rifampin moderate
- Heparin moderate
Frequently Asked Questions
What SPL severity band is on file for Aspirin + Apixaban?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Aspirin has 47 labeled pairs on file vs Apixaban's 12. In the moderate band specifically: Aspirin has 12 (also Alendronate, Desvenlafaxine, Dexamethasone, Duloxetine); Apixaban has 9 (also Clopidogrel, Warfarin, Carbamazepine, Rifampin).
What mechanism field is on file for Aspirin and Apixaban?
Aspirin and apixaban both thin the blood, and taking them together can nearly double your risk of having a bleeding event. This happens because both drugs make it harder for your blood to clot.
Aspirin carries more major-labeled pairs than Apixaban
SPL source-record counts only. This page's band is moderate · classes on file: Aspirin (Antiplatelet / NSAID); Apixaban (Direct Oral Anticoagulant (Factor Xa Inhibitor)).
Aspirin has 3 major-labeled pairs vs Apixaban's 0. This page itself is in the moderate band, not the major band.
3 major · 12 moderate · 32 minor · 47 total
- Other moderate peers for Aspirin
- Alendronate
- Desvenlafaxine
- Dexamethasone
- Duloxetine
0 major · 9 moderate · 3 minor · 12 total
- Other moderate peers for Apixaban
- Clopidogrel
- Warfarin
- Carbamazepine
- Rifampin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.