Aspirin and Ibandronate Interaction
Drug interaction information between Aspirin and Ibandronate.
Aspirin and Ibandronate have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Aspirin and Ibandronate. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these medicines can irritate your stomach and throat, which increases the chance of developing sores or pain.
FDA Label Information
Do not take within 60 minutes of dosing ( 7.1 ) Use caution when co-prescribing aspirin/nonsteroidal anti-inflammatory drugs that may worsen gastrointestinal irritation. 7.2 Aspirin/Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) Because aspirin, NSAIDs, and bisphosphonates are all associated with gastrointestinal irritation, caution should be exercised in the concomitant use of aspirin or NSAIDs with ibandronate sodium tablets.
Aspirin Also Interacts With
- Atenolol major
- Fluoxetine major
- Alendronate moderate
- Apixaban moderate
- Desvenlafaxine moderate
Frequently Asked Questions
What SPL severity band is on file for Aspirin + Ibandronate?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Aspirin has 47 labeled pairs on file vs Ibandronate's 2. In the major band specifically: Aspirin has 3 (also Atenolol, Fluoxetine); Ibandronate has 1.
What mechanism field is on file for Aspirin and Ibandronate?
Both of these medicines can irritate your stomach and throat, which increases the chance of developing sores or pain.
Aspirin carries more major-labeled pairs than Ibandronate
SPL source-record counts only. This page's band is major · classes on file: Aspirin (Antiplatelet / NSAID); Ibandronate (Bisphosphonate).
Aspirin has 3 major-labeled pairs vs Ibandronate's 1.
3 major · 12 moderate · 32 minor · 47 total
- Other major peers for Aspirin
- Atenolol
- Fluoxetine
1 major · 0 moderate · 1 minor · 2 total
Ibandronate has no other major-band peer in this dataset besides Aspirin.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.