Aspirin and Desvenlafaxine Interaction
Drug interaction information between Aspirin and Desvenlafaxine.
Aspirin and Desvenlafaxine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Aspirin and Desvenlafaxine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking these two drugs together can increase the risk of bleeding. This happens because both medications can interfere with how your blood cells stick together to form clots.
FDA Label Information
Examples NSAIDs, aspirin, and warfarin Drugs that are Primarily Metabolized by CYP2D6 Clinical Impact Concomitant use of PRISTIQ increases C max and AUC of a drug primarily metabolized by CYP2D6 which may increase the risk of toxicity of the CYP2D6 substrate drug [see Clinical Pharmacology (12.3) ] .
Aspirin Also Interacts With
- Atenolol major
- Fluoxetine major
- Ibandronate major
- Alendronate moderate
- Apixaban moderate
Desvenlafaxine Also Interacts With
- Linezolid moderate
- Phenelzine moderate
- Tranylcypromine moderate
- Selegiline moderate
- Warfarin moderate
Frequently Asked Questions
What SPL severity band is on file for Aspirin + Desvenlafaxine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Aspirin has 47 labeled pairs on file vs Desvenlafaxine's 19. In the moderate band specifically: Aspirin has 12 (also Alendronate, Apixaban, Dexamethasone, Duloxetine); Desvenlafaxine has 6 (also Linezolid, Phenelzine, Tranylcypromine, Selegiline).
What mechanism field is on file for Aspirin and Desvenlafaxine?
Taking these two drugs together can increase the risk of bleeding. This happens because both medications can interfere with how your blood cells stick together to form clots.
Aspirin carries more major-labeled pairs than Desvenlafaxine
SPL source-record counts only. This page's band is moderate · classes on file: Aspirin (Antiplatelet / NSAID); Desvenlafaxine (Serotonin-Norepinephrine Reuptake Inhibitor (SNRI)).
Aspirin has 3 major-labeled pairs vs Desvenlafaxine's 0. This page itself is in the moderate band, not the major band.
3 major · 12 moderate · 32 minor · 47 total
- Other moderate peers for Aspirin
- Alendronate
- Apixaban
- Dexamethasone
- Duloxetine
0 major · 6 moderate · 13 minor · 19 total
- Other moderate peers for Desvenlafaxine
- Linezolid
- Phenelzine
- Tranylcypromine
- Selegiline
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.