Aspirin and Fluoxetine Interaction
Drug interaction information between Aspirin and Fluoxetine.
Aspirin and Fluoxetine have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Aspirin and Fluoxetine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs can interfere with how your blood cells clump together to stop bleeding, which increases your risk of bruising or bleeding.
FDA Label Information
NSAIDs, Aspirin, Warfarin): May potentiate the risk of bleeding ( 7.4 ) Drugs Tightly Bound to Plasma Proteins: May cause a shift in plasma concentrations ( 7.6 , 7.7 ) Olanzapine: When used in combination with fluoxetine, also refer to the Drug Interactions section of the package insert for Symbyax ( 7.7 ) Drugs that Prolong the QT Interval: Do not use fluoxetine with thioridazine or pimozide. 7.4 Drugs that Interfere with Hemostasis (e.g., NSAIDs, Aspirin, Warfarin) Serotonin release by platelets plays an important role in hemostasis. Epidemiological studies of the case-control and...
Aspirin Also Interacts With
- Atenolol major
- Ibandronate major
- Alendronate moderate
- Apixaban moderate
- Desvenlafaxine moderate
Fluoxetine Also Interacts With
- Warfarin major
- Olanzapine major
- Pimozide major
- Thioridazine major
- Clonazepam major
Frequently Asked Questions
What SPL severity band is on file for Aspirin + Fluoxetine?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluoxetine has 68 labeled pairs on file vs Aspirin's 47. In the major band specifically: Aspirin has 3 (also Atenolol, Ibandronate); Fluoxetine has 6 (also Warfarin, Olanzapine, Pimozide, Thioridazine).
What mechanism field is on file for Aspirin and Fluoxetine?
Both drugs can interfere with how your blood cells clump together to stop bleeding, which increases your risk of bruising or bleeding.
Fluoxetine carries more major-labeled pairs than Aspirin
SPL source-record counts only. This page's band is major · classes on file: Aspirin (Antiplatelet / NSAID); Fluoxetine (Selective Serotonin Reuptake Inhibitor (SSRI)).
Fluoxetine has 6 major-labeled pairs vs Aspirin's 3.
3 major · 12 moderate · 32 minor · 47 total
- Other major peers for Aspirin
- Atenolol
- Ibandronate
6 major · 19 moderate · 43 minor · 68 total
- Other major peers for Fluoxetine
- Warfarin
- Olanzapine
- Pimozide
- Thioridazine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.