Aspirin and Edoxaban Interaction
Drug interaction information between Aspirin and Edoxaban.
Aspirin and Edoxaban have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Aspirin and Edoxaban. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs affect how your blood clots, which can lead to more bleeding when used together.
FDA Label Information
Promptly evaluate any signs or symptoms of blood loss if patients are treated concomitantly with anticoagulants, aspirin, other platelet aggregation inhibitors, and/or NSAIDs [see Warnings and Precautions (5.3) ] . In clinical studies with SAVAYSA concomitant use of aspirin (low dose ≤ 100 mg/day) or thienopyridines, and NSAIDs was permitted and resulted in increased rates of Clinically Relevant Bleeding. Carefully monitor for bleeding in patients who require chronic treatment with low dose aspirin and/or NSAIDs [see Warnings and Precautions (5.3) and Clinical Pharmacology (12.3) ] .
Aspirin Also Interacts With
- Atenolol major
- Fluoxetine major
- Ibandronate major
- Alendronate moderate
- Apixaban moderate
Edoxaban Also Interacts With
- Rifampin moderate
- Norepinephrine moderate
- Carbamazepine minor
- Darunavir minor
Frequently Asked Questions
What SPL severity band is on file for Aspirin + Edoxaban?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Aspirin has 47 labeled pairs on file vs Edoxaban's 5. In the minor band specifically: Aspirin has 32 (also Carisoprodol, Celecoxib, Colestipol, Diflunisal); Edoxaban has 3 (also Carbamazepine, Darunavir).
What mechanism field is on file for Aspirin and Edoxaban?
Both drugs affect how your blood clots, which can lead to more bleeding when used together.
Aspirin carries more major-labeled pairs than Edoxaban
SPL source-record counts only. This page's band is minor · classes on file: Aspirin (Antiplatelet / NSAID); Edoxaban (Direct Oral Anticoagulant (Factor Xa Inhibitor)).
Aspirin has 3 major-labeled pairs vs Edoxaban's 0. This page itself is in the minor band, not the major band.
3 major · 12 moderate · 32 minor · 47 total
- Other minor peers for Aspirin
- Carisoprodol
- Celecoxib
- Colestipol
- Diflunisal
0 major · 2 moderate · 3 minor · 5 total
- Other minor peers for Edoxaban
- Carbamazepine
- Darunavir
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.