Cidofovir and Amikacin Interaction
Drug interaction information between Cidofovir and Amikacin.
Cidofovir and Amikacin have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Cidofovir and Amikacin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these drugs can be harmful to the kidneys. Using them together significantly increases the chance of kidney injury.
FDA Label Information
Nephrotoxic agents Concomitant administration of cidofovir injection and agents with nephrotoxic potential [e.g., intravenous aminoglycosides (e.g., tobramycin, gentamicin, and amikacin), amphotericin B, foscarnet, intravenous pentamidine, vancomycin, and nonsteroidal anti-inflammatory agents] is contraindicated.
Cidofovir Also Interacts With
- Vancomycin major
- Gentamicin major
- Tobramycin major
- Amphotericin B major
- Furosemide minor
Frequently Asked Questions
What SPL severity band is on file for Cidofovir + Amikacin?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cidofovir has 16 labeled pairs on file vs Amikacin's 2. In the major band specifically: Cidofovir has 5 (also Vancomycin, Gentamicin, Tobramycin, Amphotericin B); Amikacin has 1.
What mechanism field is on file for Cidofovir and Amikacin?
Both of these drugs can be harmful to the kidneys. Using them together significantly increases the chance of kidney injury.
Cidofovir carries more major-labeled pairs than Amikacin
SPL source-record counts only. This page's band is major · classes on file: Cidofovir (Antiviral (Nucleotide Analog)); Amikacin (Aminoglycoside Antibiotic).
Cidofovir has 5 major-labeled pairs vs Amikacin's 1.
5 major · 0 moderate · 11 minor · 16 total
- Other major peers for Cidofovir
- Vancomycin
- Gentamicin
- Tobramycin
- Amphotericin B
1 major · 0 moderate · 1 minor · 2 total
Amikacin has no other major-band peer in this dataset besides Cidofovir.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.