Cidofovir and Tobramycin Interaction
Drug interaction information between Cidofovir and Tobramycin.
Cidofovir and Tobramycin have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Cidofovir and Tobramycin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs have the potential to damage your kidneys. Taking them together adds to this risk and can lead to kidney failure.
FDA Label Information
Nephrotoxic agents Concomitant administration of cidofovir injection and agents with nephrotoxic potential [e.g., intravenous aminoglycosides (e.g., tobramycin, gentamicin, and amikacin), amphotericin B, foscarnet, intravenous pentamidine, vancomycin, and nonsteroidal anti-inflammatory agents] is contraindicated.
Cidofovir Also Interacts With
- Vancomycin major
- Gentamicin major
- Amikacin major
- Amphotericin B major
- Furosemide minor
Frequently Asked Questions
What SPL severity band is on file for Cidofovir + Tobramycin?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cidofovir has 16 labeled pairs on file vs Tobramycin's 2. In the major band specifically: Cidofovir has 5 (also Vancomycin, Gentamicin, Amikacin, Amphotericin B); Tobramycin has 1.
What mechanism field is on file for Cidofovir and Tobramycin?
Both drugs have the potential to damage your kidneys. Taking them together adds to this risk and can lead to kidney failure.
Cidofovir carries more major-labeled pairs than Tobramycin
SPL source-record counts only. This page's band is major · classes on file: Cidofovir (Antiviral (Nucleotide Analog)); Tobramycin (Aminoglycoside Antibiotic).
Cidofovir has 5 major-labeled pairs vs Tobramycin's 1.
5 major · 0 moderate · 11 minor · 16 total
- Other major peers for Cidofovir
- Vancomycin
- Gentamicin
- Amikacin
- Amphotericin B
1 major · 0 moderate · 1 minor · 2 total
Tobramycin has no other major-band peer in this dataset besides Cidofovir.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.