Cidofovir and Furosemide Interaction
Drug interaction information between Cidofovir and Furosemide.
Cidofovir and Furosemide have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Cidofovir and Furosemide. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Probenecid is given with cidofovir and can slow down how the kidneys remove furosemide from the body. This can lead to higher levels of furosemide in your blood.
What To Do
Your doctor may need to adjust your dose of furosemide. Monitor your response to the medication closely.
FDA Label Information
Drug Interactions Probenecid Probenecid is known to interact with the metabolism or renal tubular excretion of many drugs (e.g., acetaminophen, acyclovir, angiotensin-converting enzyme inhibitors, aminosalicylic acid, barbiturates, benzodiazepines, bumetanide, clofibrate, methotrexate, famotidine, furosemide, nonsteroidal anti-inflammatory agents, theophylline, and zidovudine).
Cidofovir Also Interacts With
- Vancomycin major
- Gentamicin major
- Tobramycin major
- Amikacin major
- Amphotericin B major
Furosemide Also Interacts With
- Dutasteride major
- Dutasteride/Tamsulosin major
- Tamsulosin major
- Cyclosporine moderate
- Lithium moderate
Frequently Asked Questions
Can I take Cidofovir and Furosemide together?
This is a minor interaction. Your doctor may need to adjust your dose of furosemide. Monitor your response to the medication closely.
How serious is the interaction between Cidofovir and Furosemide?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Cidofovir and Furosemide interact?
Probenecid is given with cidofovir and can slow down how the kidneys remove furosemide from the body. This can lead to higher levels of furosemide in your blood.
Understanding the Cidofovir and Furosemide Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Cidofovir belongs to the Antiviral (Nucleotide Analog) class and Furosemide belongs to the Loop Diuretic class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Probenecid is given with cidofovir and can slow down how the kidneys remove furosemide from the body. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Cidofovir has 16 total documented interactions on file in this dataset, and Furosemide has 36. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your doctor may need to adjust your dose of furosemide. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Cidofovir or Furosemide based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.