Cidofovir and Vancomycin Interaction
Drug interaction information between Cidofovir and Vancomycin.
Cidofovir and Vancomycin have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Cidofovir and Vancomycin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs can harm the kidneys. Taking them at the same time increases the risk of serious kidney damage.
FDA Label Information
Nephrotoxic agents Concomitant administration of cidofovir injection and agents with nephrotoxic potential [e.g., intravenous aminoglycosides (e.g., tobramycin, gentamicin, and amikacin), amphotericin B, foscarnet, intravenous pentamidine, vancomycin, and nonsteroidal anti-inflammatory agents] is contraindicated.
Cidofovir Also Interacts With
- Gentamicin major
- Tobramycin major
- Amikacin major
- Amphotericin B major
- Furosemide minor
Vancomycin Also Interacts With
- Colistin minor
- Amphotericin B minor
- Piperacillin/Tazobactam minor
- Rosiglitazone minor
- Trospium minor
Frequently Asked Questions
What SPL severity band is on file for Cidofovir + Vancomycin?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cidofovir has 16 labeled pairs on file vs Vancomycin's 6. In the major band specifically: Cidofovir has 5 (also Gentamicin, Tobramycin, Amikacin, Amphotericin B); Vancomycin has 1.
What mechanism field is on file for Cidofovir and Vancomycin?
Both drugs can harm the kidneys. Taking them at the same time increases the risk of serious kidney damage.
Cidofovir carries more major-labeled pairs than Vancomycin
SPL source-record counts only. This page's band is major · classes on file: Cidofovir (Antiviral (Nucleotide Analog)); Vancomycin (Glycopeptide Antibiotic).
Cidofovir has 5 major-labeled pairs vs Vancomycin's 1.
5 major · 0 moderate · 11 minor · 16 total
- Other major peers for Cidofovir
- Gentamicin
- Tobramycin
- Amikacin
- Amphotericin B
1 major · 0 moderate · 5 minor · 6 total
Vancomycin has no other major-band peer in this dataset besides Cidofovir.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.