Amiloride and Perindopril Interaction
Drug interaction information between Amiloride and Perindopril.
Amiloride and Perindopril have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Amiloride and Perindopril. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs prevent your kidneys from removing potassium, which can lead to a buildup in your system.
FDA Label Information
Use of potassium-sparing diuretics (spironolactone, amiloride, triamterene and others), potassium supplements or other drugs capable of increasing serum potassium (indomethacin, heparin, cyclosporine and others) can increase the risk of hyperkalemia.
Amiloride Also Interacts With
- Potassium Chloride major
- Cyclosporine moderate
- Lithium moderate
- Amlodipine/Benazepril moderate
- Benazepril moderate
Perindopril Also Interacts With
- Aliskiren major
- Spironolactone moderate
- Cyclosporine moderate
- Indomethacin moderate
- Heparin moderate
Frequently Asked Questions
What SPL severity band is on file for Amiloride + Perindopril?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Amiloride has 19 labeled pairs on file vs Perindopril's 9. In the moderate band specifically: Amiloride has 7 (also Cyclosporine, Lithium, Amlodipine/Benazepril, Benazepril); Perindopril has 5 (also Spironolactone, Cyclosporine, Indomethacin, Heparin).
What mechanism field is on file for Amiloride and Perindopril?
Both drugs prevent your kidneys from removing potassium, which can lead to a buildup in your system.
Amiloride's labeled portfolio outnumbers Perindopril
SPL source-record counts only. This page's band is moderate · classes on file: Amiloride (Potassium-Sparing Diuretic); Perindopril (ACE Inhibitor).
1 major · 7 moderate · 11 minor · 19 total
- Other moderate peers for Amiloride
- Cyclosporine
- Lithium
- Amlodipine/Benazepril
- Benazepril
1 major · 5 moderate · 3 minor · 9 total
- Other moderate peers for Perindopril
- Spironolactone
- Cyclosporine
- Indomethacin
- Heparin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.