amiloride vs perindopril
Side-by-side comparison of amiloride and perindopril. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
moderate Known Drug Interaction
Use of potassium-sparing diuretics (spironolactone, amiloride, triamterene and others), potassium supplements or other drugs capable of increasing serum potassium (indomethacin, heparin, cyclosporine and others) can increase the risk of hyperkalemia.
Recommendation: Your healthcare provider should monitor your potassium levels regularly. Avoid using potassium-based salt substitutes.
Midamor
Aceon
Amiloride is a water pill that helps your body hold onto potassium. It is often used with other water pills to prevent low potassium levels.
Perindopril (Aceon) is a drug that lowers blood pressure. It can also help reduce the risk of heart problems in people with stable coronary artery disease.
Amiloride treats high blood pressure and heart failure. It helps restore normal potassium levels if you develop low potassium while taking other water pills. It can also prevent low potassium if you are at risk, such as if you take digoxin or have heart rhythm problems. Amiloride is not usually prescribed alone.
Perindopril treats high blood pressure (hypertension). It can be used alone or with other blood pressure medicines. Perindopril also helps lower the risk of heart-related death or heart attack in people who have stable coronary artery disease. It can be used with other treatments for coronary artery disease.
Amiloride blocks sodium channels in your kidneys. This action reduces the amount of potassium lost in your urine. This helps to maintain or increase potassium levels in your body.
Perindopril belongs to a class of drugs called ACE inhibitors. It works by relaxing your blood vessels, which lowers blood pressure. This makes it easier for your heart to pump blood.
- • Headache
- • Nausea
- • Loss of appetite
- • Diarrhea
- • Vomiting
- • Cough
- • Dizziness
- • Back pain
- Shortness of breath 69
- Diarrhea 57
- Feeling sick to your stomach 49
- Throwing up 39
- Tiredness 37
No adverse event reports.
Amiloride can cause high potassium levels, which can be dangerous. You should not take this medicine if you already have high potassium, kidney problems, or are taking other potassium-sparing diuretics or potassium supplements. Your doctor should check your potassium levels regularly.
If you become pregnant, stop taking perindopril right away. This medicine can cause serious harm or death to an unborn baby.
Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. It is not known if amiloride can harm an unborn baby or pass into breast milk.
Do not take perindopril if you are pregnant. It can cause harm to your unborn baby, especially during the second and third trimesters. It is not known if perindopril passes into breast milk, so talk to your doctor before breastfeeding.
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How to Read This amiloride vs perindopril Comparison
amiloride is classified in the Potassium-Sparing Diuretic drug class, while perindopril sits within the ACE Inhibitor class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, amiloride has 251 submissions while perindopril has 0. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known moderate interaction flagged in FDA labeling, attributed to both drugs prevent your kidneys from removing potassium, which can lead to a buildup in your system.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between amiloride and perindopril - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.