HIGH-VOLUME · SEX-BALANCED
bupropion Side Effects
bupropion (also sold as Wellbutrin, Zyban) is HIGH-VOLUME in this FAERS book #157 of 524 by FAERS report count. Signature opener: SEX-BALANCED - 66% of sex-coded reports are female (24,398 F / 12,560 M).
Data updated 2026-05-15
- 41,778
- FAERS reports
FAERS voluntary reports, 2004 to 2025. High volume tracks exposure and reporting culture; see methodology for de-dup rules.
bupropion reporting skew - 66% of sex-coded reports are female (24,398 F / 12,560 M). Volume band HIGH-VOLUME #157 of 524 by FAERS report count; caseload CASELOAD.
High-report extract for bupropion (Wellbutrin): 41,778 FAERS rows (2004-2025). Top named reactions: COMPLETED SUICIDE, TOXICITY TO VARIOUS AGENTS, FATIGUE. Outcome stamps DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED. FAERS is voluntary signal detection, not incidence.
Counts from the openFDA FAERS extract (2004–2025). Stamps CASELOAD · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
COMPLETED SUICIDE leads 4,408 of 41,778 reports
Who reports · age peak 45-64 (SEX-BALANCED)
Sex coding · SEX-BALANCED
Age peak 45-64 (12,586 reports)
FAERS filings rising toward 2025
Reactions in Death Reports
Death-mentioned subset is HEAVY here (8,506 reports, 20.4%). Top co-reported reactions in that subset - voluntary, not causal.
| Reaction | Reports |
|---|---|
| COMPLETED SUICIDE | 4,401 |
| TOXICITY TO VARIOUS AGENTS | 2,185 |
| DEATH | 1,036 |
| CARDIO-RESPIRATORY ARREST | 813 |
| CARDIAC ARREST | 689 |
| DRUG ABUSE | 586 |
| SUSPECTED SUICIDE | 583 |
| OVERDOSE | 491 |
| RESPIRATORY ARREST | 436 |
| INTENTIONAL OVERDOSE | 258 |
| HYPOTENSION | 233 |
| FATIGUE | 207 |
| DEPRESSION | 197 |
| INTENTIONAL PRODUCT MISUSE | 196 |
| DRUG INTERACTION | 186 |
| POISONING | 186 |
| PAIN | 174 |
| HEADACHE | 165 |
Reactions in Hospitalization Reports
Hospitalization is HEAVY (13,230, 31.7% of the book). Top reactions in those rows:
| Reaction | Reports |
|---|---|
| COMPLETED SUICIDE | 1,580 |
| TOXICITY TO VARIOUS AGENTS | 1,475 |
| OVERDOSE | 1,251 |
| INTENTIONAL OVERDOSE | 1,095 |
| SEIZURE | 895 |
| DRUG INTERACTION | 789 |
| NAUSEA | 713 |
| HYPOTENSION | 675 |
| SEROTONIN SYNDROME | 665 |
| DYSPNOEA | 623 |
| FATIGUE | 587 |
| SUICIDE ATTEMPT | 579 |
| HEADACHE | 576 |
| CARDIAC ARREST | 574 |
| FALL | 572 |
| PAIN | 563 |
| ANXIETY | 552 |
| PNEUMONIA | 548 |
How to read bupropion FAERS figures (CASELOAD · DEATH-HEAVY · HOSP-HEAVY)
FAERS holds 41,778 voluntary reports linked to bupropion (Wellbutrin, Zyban), 2004-2025. Death is listed on 8,506 (20.4%). Hospitalization appears on 13,230 (31.7%). Top co-reported indication: Product Used For Unknown Indication.
CASELOAD books overweight common drugs and loud reporting cultures; SEX-BALANCED is the page opener, not a per-patient risk.
Read with bupropion
Peers ranked by ABS(total_reports), then an ABS(death_share) pole; guide hop follows DEATH-HEAVY · HOSP-HEAVY stamps.
ABS(total_reports) peer at 41,632 FAERS cases (Δ 146 lighter vs bupropion); DEATH-HEAVY · HOSP-MID · SEX-BALANCED vs this page's CASELOAD · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
ABS(total_reports) peer at 42,504 FAERS cases (Δ 726 heavier vs bupropion); DEATH-HEAVY · HOSP-MID · SEX-BALANCED vs this page's CASELOAD · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
ABS(total_reports) peer at 40,954 FAERS cases (Δ 824 lighter vs bupropion); DEATH-MARKED · HOSP-MID · MALE-LED vs this page's CASELOAD · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
ABS(total_reports) peer at 42,665 FAERS cases (Δ 887 heavier vs bupropion); DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED vs this page's CASELOAD · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
ABS(death_share) pole at 62.1% death-mentioned reports (Δ 41.7 pp vs bupropion's DEATH-HEAVY): CASELOAD · HOSP-MID.
bupropion stamps DEATH-HEAVY · HOSP-HEAVY; FAERS outcome shares are signal-detection rates, not incidence. Read them next to caseload CASELOAD and the label guide.