amoxicillin/clavulanate

( 7.1 ) Concomitant use of AUGMENTIN and oral anticoagulants may increase the prolongation of prothrombin time.( 7.2 ) Co-administration with allopurinol increases the risk of rash. 7.3 Allopurinol The concurrent administration of allopurinol and amoxicillin increases the incidence of rashes in patients receiving both drugs as compared to patients receiving amoxicillin alone. It is not known whether this potentiation of amoxicillin rashes is due to allopurinol or the hyperuricemia present in these patients.

Mechanism: Taking these two drugs together increases the chance of developing a skin rash. It is not fully known if the rash is caused by the drugs themselves or the medical condition being treated.

What to do: Watch your skin closely for any new rashes and tell your doctor immediately if one appears. Your doctor may need to monitor your reaction to these medications.

7 DRUG INTERACTIONS Co‑administration with probenecid is not recommended. ( 7.4 ) 7.1 Probenecid Probenecid decreases the renal tubular secretion of amoxicillin but does not delay renal excretion of clavulanic acid. Co-administration of probenecid is not recommended.

Mechanism: Probenecid slows down the kidneys from clearing amoxicillin out of your system, which can lead to higher levels of the drug in your body. It does not affect how the other part of the medicine, clavulanic acid, is removed.

What to do: This combination is not recommended by the manufacturer. Talk to your doctor about alternative treatments or necessary adjustments to your prescription.

( 7.4 ) 7.1 Probenecid Probenecid decreases the renal tubular secretion of amoxicillin but does not delay renal excretion of clavulanic acid. Concurrent use with AUGMENTIN may result in increased and prolonged blood concentrations of amoxicillin. 7.2 Oral Anticoagulants Abnormal prolongation of prothrombin time (increased international normalized ratio [INR]) has been reported in patients receiving amoxicillin and oral anticoagulants.

Mechanism: This antibiotic can interfere with how your blood clots when it is taken with blood-thinning medications.

What to do: Your doctor may need to check your blood clotting time more often and adjust your blood thinner dose.

Following administration of amoxicillin to pregnant women, a transient decrease in plasma concentration of total conjugated estriol, estriol-glucuronide, conjugated estrone, and estradiol has been noted.

Mechanism: This medication can cause a temporary drop in the levels of estrogen hormones found in your blood.

What to do: Consult your healthcare provider to see if you need to monitor your hormone levels or use additional birth control.

7.4 Oral Contraceptives AUGMENTIN may affect intestinal flora, leading to lower estrogen reabsorption and reduced efficacy of combined oral estrogen/progesterone contraceptives.

Mechanism: This antibiotic can change the bacteria in your gut, which makes it harder for your body to absorb the hormones in birth control pills.

What to do: Use a backup method of birth control, such as condoms, while taking this antibiotic to prevent pregnancy.