Prescription medication · Penicillin / Beta-Lactamase Inhibitor Combination

amoxicillin/clavulanate

Name: amoxicillin/clavulanate - FDA Drug Safety & Adverse Event Data
Creator: PlainMeds
License: https://creativecommons.org/publicdomain/zero/1.0/

Also sold as Augmentin. Augmentin treats infections caused by bacteria.

Compiled by PlainMeds, Drug Information Editorial Process

Data updated 2026-05-15

37,433
FDA reports: 5
InteractionsFew interactions: $5.78
Brand price (NADAC)

What the data shows

amoxicillin/clavulanate (Augmentin) is a prescription Penicillin / Beta-Lactamase Inhibitor Combination, with 37,433 FDA adverse-event reports on file, with 5 documented drug interactions.

Reporting volume reflects how widely a drug is used and studied, not how dangerous it is, a FAERS report documents a temporal association, never proof of cause.

amoxicillin/clavulanate (Augmentin) is a prescription Penicillin / Beta-Lactamase Inhibitor Combination. Augmentin treats infections caused by bacteria.

Augmentin is a combination of two medicines, amoxicillin and clavulanate. It is an antibiotic that fights bacteria in your body.

Verify with FDA → · CMS NADAC pricing →

Drug Pricing (NADAC)

Brand Price

$5.78/unit

Generic Available

Pricing data from NADAC (CMS), effective December 18, 2024. Compare all drug costs →

Compare with Another Drug →

What it does

Augmentin treats infections caused by bacteria.

Common side effects

Diarrhea or loose stools, Nausea, Skin rashes

Key warnings

Augmentin can cause serious allergic reactions, including fatal ones.

The sections below are summarized in plain English from amoxicillin/clavulanate's FDA-approved prescribing information. They describe what the official label says, and are not personal medical advice.

How It Works

Amoxicillin kills bacteria. Clavulanate helps amoxicillin work better by preventing bacteria from breaking down amoxicillin. This combination helps to fight a wider range of bacteria.

Side Effects (from patient reports)

Based on 37,433 FDA adverse event reports.

Long-term kidney disease

4,661
Sudden kidney damage

4,200
Diarrhea

4,083
Drug allergy

3,744
Feeling sick to your stomach

3,700
Difficulty breathing

3,623
Pain

3,570
Skin rash

3,539
Tiredness

3,270
Kidney failure

3,043

What this shows Bars show how often each reaction was reported, not how likely it is to happen, a report records a temporal association, never proof that the drug caused it.

Serious Warnings

Augmentin can cause serious allergic reactions, including fatal ones. Stop taking Augmentin and get medical help right away if you have any signs of an allergic reaction. Augmentin can also cause severe skin reactions. Tell your doctor if you develop a rash. This drug can also cause liver problems and severe diarrhea.

Known Drug Interactions

moderate allopurinol

( 7.1 ) Concomitant use of AUGMENTIN and oral anticoagulants may increase the prolongation of prothrombin time.( 7.2 ) Co-administration with allopurinol increases the risk of rash. 7.3 Allopurinol The concurrent administration of allopurinol and amoxicillin increases the incidence of rashes in patients receiving both drugs as compared to patients receiving amoxicillin alone. It is not known whether this potentiation of amoxicillin rashes is due to allopurinol or the hyperuricemia present in these patients.

Mechanism: Taking these two drugs together increases the chance of developing a skin rash. It is not fully known if the rash is caused by the drugs themselves or the medical condition being treated.

moderate probenecid

7 DRUG INTERACTIONS Co‑administration with probenecid is not recommended. ( 7.4 ) 7.1 Probenecid Probenecid decreases the renal tubular secretion of amoxicillin but does not delay renal excretion of clavulanic acid. Co-administration of probenecid is not recommended.

Mechanism: Probenecid slows down the kidneys from clearing amoxicillin out of your system, which can lead to higher levels of the drug in your body. It does not affect how the other part of the medicine, clavulanic acid, is removed.

minor amoxicillin

( 7.4 ) 7.1 Probenecid Probenecid decreases the renal tubular secretion of amoxicillin but does not delay renal excretion of clavulanic acid. Concurrent use with AUGMENTIN may result in increased and prolonged blood concentrations of amoxicillin. 7.2 Oral Anticoagulants Abnormal prolongation of prothrombin time (increased international normalized ratio [INR]) has been reported in patients receiving amoxicillin and oral anticoagulants.

Mechanism: This antibiotic can interfere with how your blood clots when it is taken with blood-thinning medications.

minor estradiol

Following administration of amoxicillin to pregnant women, a transient decrease in plasma concentration of total conjugated estriol, estriol-glucuronide, conjugated estrone, and estradiol has been noted.

Mechanism: This medication can cause a temporary drop in the levels of estrogen hormones found in your blood.

minor progesterone

7.4 Oral Contraceptives AUGMENTIN may affect intestinal flora, leading to lower estrogen reabsorption and reduced efficacy of combined oral estrogen/progesterone contraceptives.

Mechanism: This antibiotic can change the bacteria in your gut, which makes it harder for your body to absorb the hormones in birth control pills.

This is a plain-language summary of FDA-label interaction records and does not provide individual medication-combination directions.

Common Questions

Can I use Augmentin for a cold?

No, Augmentin is an antibiotic and only works against bacteria. It will not work for colds or other viral infections.

What should I do if I get diarrhea while taking Augmentin?

Tell your doctor if you get diarrhea. It could be a sign of a more serious infection.

Can I take Augmentin if I am allergic to penicillin?

You should not take Augmentin if you are allergic to penicillin or other beta-lactam antibiotics.

Does Augmentin interact with birth control pills?

Augmentin may make birth control pills less effective. Talk to your doctor about using another form of birth control while taking Augmentin.

Can I drink alcohol while taking Augmentin?

It is best to avoid alcohol while taking Augmentin.

How long should I take Augmentin?

Take Augmentin for the full course of treatment, even if you feel better. Stopping early may allow the infection to come back.

What if I feel sick to my stomach when I take Augmentin?

Take Augmentin at the start of a meal to help prevent stomach upset.

Can Augmentin cause a rash?

Yes, Augmentin can cause a rash. If you develop a rash, tell your doctor right away.

Is it okay to share my Augmentin with someone else?

No, never share your antibiotics with anyone else, even if they have similar symptoms.

What should I do with leftover Augmentin?

Ask your pharmacist how to properly dispose of any unused Augmentin.

What are the common side effects of amoxicillin/clavulanate?

The registry lists Diarrhea or loose stools, Nausea, Skin rashes, Hives, Vomiting among the most-reported FAERS reaction terms for amoxicillin/clavulanate. The compiled record contains 37,433 FDA adverse-event reports. These counts are not an individual symptom assessment.

Does amoxicillin/clavulanate interact with other medications?

The registry has 5 documented interaction rows for amoxicillin/clavulanate. Notable source-record pairings include allopurinol, probenecid, amoxicillin. These rows are not a complete medication review.

What drug class is amoxicillin/clavulanate?

amoxicillin/clavulanate belongs to the Penicillin / Beta-Lactamase Inhibitor Combination drug class. It requires a prescription (Rx). Augmentin treats infections caused by bacteria.

What pregnancy or breastfeeding source fields are listed for amoxicillin/clavulanate?

The FDA label for amoxicillin/clavulanate contains product-specific pregnancy or breastfeeding language. PlainMeds does not apply that source text to an individual.

Other drugs grouped near amoxicillin/clavulanate - same-class peers and common alternatives.

amikacin

Amikin

Amikacin is an antibiotic medicine.