Zonisamide and Carbamazepine Interaction
Drug interaction information between Zonisamide and Carbamazepine.
Zonisamide and Carbamazepine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Zonisamide and Carbamazepine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Carbamazepine speeds up how quickly your body breaks down zonisamide, which can make the zonisamide less effective.
FDA Label Information
In addition, carbamazepine causes, or would be expected to cause, decreased levels of the following drugs, for which monitoring of concentrations or dosage adjustment may be necessary: acetaminophen, albendazole, alprazolam, aprepitant, buprenorphone, bupropion, citalopram, clonazepam, clozapine, corticosteroids (e.g., prednisolone, dexamethasone), cyclosporine, dicumarol, dihydropyridine calcium channel blockers (e.g., felodipine), doxycycline, ethosuximide, everolimus, haloperidol, imatinib, itraconazole, lamotrigine, levothyroxine, methadone, methsuximide, mianserin, midazolam,...
Zonisamide Also Interacts With
- Alogliptin moderate
- Ertugliflozin moderate
- Topiramate moderate
- Empagliflozin minor
- Empagliflozin/Linagliptin minor
Carbamazepine Also Interacts With
- Nirmatrelvir/Ritonavir major
- Ranolazine major
- Risperidone major
- Lithium moderate
- Apixaban moderate
Frequently Asked Questions
What SPL severity band is on file for Zonisamide + Carbamazepine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Carbamazepine has 129 labeled pairs on file vs Zonisamide's 13. In the minor band specifically: Zonisamide has 10 (also Empagliflozin, Empagliflozin/Linagliptin, Linagliptin, Metformin); Carbamazepine has 110 (also Omeprazole, Ibuprofen, Citalopram, Amitriptyline).
What mechanism field is on file for Zonisamide and Carbamazepine?
Carbamazepine speeds up how quickly your body breaks down zonisamide, which can make the zonisamide less effective.
Carbamazepine carries more major-labeled pairs than Zonisamide
SPL source-record counts only. This page's band is minor · classes on file: Zonisamide (Anticonvulsant (Sulfonamide)); Carbamazepine (Anticonvulsant).
Carbamazepine has 3 major-labeled pairs vs Zonisamide's 0. This page itself is in the minor band, not the major band.
0 major · 3 moderate · 10 minor · 13 total
- Other minor peers for Zonisamide
- Empagliflozin
- Empagliflozin/Linagliptin
- Linagliptin
- Metformin
3 major · 16 moderate · 110 minor · 129 total
- Other minor peers for Carbamazepine
- Omeprazole
- Ibuprofen
- Citalopram
- Amitriptyline
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.