Zonisamide and Ertugliflozin Interaction
Drug interaction information between Zonisamide and Ertugliflozin.
Zonisamide and Ertugliflozin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Zonisamide and Ertugliflozin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs can cause a buildup of acid in the blood. Taking them together increases the risk of a serious condition called lactic acidosis.
FDA Label Information
7 DRUG INTERACTIONS Table 3: Clinically Significant Drug Interactions with SEGLUROMET Carbonic Anhydrase Inhibitors Clinical Impact: The risk of lactic acidosis may increase due to concomitant use of Topiramate or other carbonic anhydrase inhibitors (e.g., zonisamide, acetazolamide or dichlorphenamide) with metformin.
Zonisamide Also Interacts With
- Alogliptin moderate
- Topiramate moderate
- Carbamazepine minor
- Empagliflozin minor
- Empagliflozin/Linagliptin minor
Ertugliflozin Also Interacts With
- Metformin moderate
- Topiramate moderate
- Dolutegravir moderate
- Ranolazine moderate
- Cimetidine moderate
Frequently Asked Questions
What SPL severity band is on file for Zonisamide + Ertugliflozin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Zonisamide has 13 labeled pairs on file vs Ertugliflozin's 8. In the moderate band specifically: Zonisamide has 3 (also Alogliptin, Topiramate); Ertugliflozin has 6 (also Metformin, Topiramate, Dolutegravir, Ranolazine).
What mechanism field is on file for Zonisamide and Ertugliflozin?
Both drugs can cause a buildup of acid in the blood. Taking them together increases the risk of a serious condition called lactic acidosis.
Zonisamide's labeled portfolio outnumbers Ertugliflozin
SPL source-record counts only. This page's band is moderate · classes on file: Zonisamide (Anticonvulsant (Sulfonamide)); Ertugliflozin (SGLT2 Inhibitor).
0 major · 3 moderate · 10 minor · 13 total
- Other moderate peers for Zonisamide
- Alogliptin
- Topiramate
0 major · 6 moderate · 2 minor · 8 total
- Other moderate peers for Ertugliflozin
- Metformin
- Topiramate
- Dolutegravir
- Ranolazine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.