Zonisamide and Empagliflozin/Linagliptin Interaction
Drug interaction information between Zonisamide and Empagliflozin/Linagliptin.
Zonisamide and Empagliflozin/Linagliptin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Zonisamide and Empagliflozin/Linagliptin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Zonisamide can cause a buildup of acid in your blood by changing how your kidneys handle certain chemicals.
Zonisamide Also Interacts With
- Alogliptin moderate
- Ertugliflozin moderate
- Topiramate moderate
- Carbamazepine minor
- Empagliflozin minor
Empagliflozin/Linagliptin Also Interacts With
- Metformin moderate
- Dolutegravir moderate
- Ranolazine moderate
- Cimetidine moderate
- Empagliflozin minor
Frequently Asked Questions
What SPL severity band is on file for Zonisamide + Empagliflozin/Linagliptin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Zonisamide has 13 labeled pairs on file vs Empagliflozin/Linagliptin's 11. In the minor band specifically: Zonisamide has 10 (also Carbamazepine, Empagliflozin, Linagliptin, Metformin); Empagliflozin/Linagliptin has 7 (also Empagliflozin, Topiramate, Lithium, Rifampin).
What mechanism field is on file for Zonisamide and Empagliflozin/Linagliptin?
Zonisamide can cause a buildup of acid in your blood by changing how your kidneys handle certain chemicals.
Zonisamide's labeled portfolio outnumbers Empagliflozin/Linagliptin
SPL source-record counts only. This page's band is minor · classes on file: Zonisamide (Anticonvulsant (Sulfonamide)); Empagliflozin/Linagliptin (SGLT2 / DPP-4 Combination).
0 major · 3 moderate · 10 minor · 13 total
- Other minor peers for Zonisamide
- Carbamazepine
- Empagliflozin
- Linagliptin
- Metformin
0 major · 4 moderate · 7 minor · 11 total
- Other minor peers for Empagliflozin/Linagliptin
- Empagliflozin
- Topiramate
- Lithium
- Rifampin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.