Rifampin and Probenecid Interaction
Drug interaction information between Rifampin and Probenecid.
Rifampin and Probenecid have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Rifampin and Probenecid. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Probenecid causes rifampin to build up in your body, which can lead to harmful side effects or toxicity.
FDA Label Information
Concomitant use with probenecid and cotrimoxazole increases the concentration of rifampin which may increase the risk of RIFADIN toxicities.
Rifampin Also Interacts With
- Darunavir major
- Bictegravir/Emtricitabine/Tenofovir major
- Glecaprevir/Pibrentasvir major
- Nirmatrelvir/Ritonavir major
- Pitavastatin major
Probenecid Also Interacts With
- Ketorolac major
- Levofloxacin major
- Amoxicillin moderate
- Amoxicillin/Clavulanate moderate
- Ceftazidime/Avibactam moderate
Frequently Asked Questions
What SPL severity band is on file for Rifampin + Probenecid?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Rifampin has 137 labeled pairs on file vs Probenecid's 37. In the moderate band specifically: Rifampin has 26 (also Doxycycline, Theophylline, Apixaban, Aprepitant); Probenecid has 12 (also Amoxicillin, Amoxicillin/Clavulanate, Ceftazidime/Avibactam, Cefuroxime).
What mechanism field is on file for Rifampin and Probenecid?
Probenecid causes rifampin to build up in your body, which can lead to harmful side effects or toxicity.
Rifampin carries more major-labeled pairs than Probenecid
SPL source-record counts only. This page's band is moderate · classes on file: Rifampin (Rifamycin Antibiotic); Probenecid (Uricosuric Agent).
Rifampin has 8 major-labeled pairs vs Probenecid's 2. This page itself is in the moderate band, not the major band.
8 major · 26 moderate · 103 minor · 137 total
- Other moderate peers for Rifampin
- Doxycycline
- Theophylline
- Apixaban
- Aprepitant
2 major · 12 moderate · 23 minor · 37 total
- Other moderate peers for Probenecid
- Amoxicillin
- Amoxicillin/Clavulanate
- Ceftazidime/Avibactam
- Cefuroxime
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.