Rifampin and Apixaban Interaction
Drug interaction information between Rifampin and Apixaban.
Rifampin and Apixaban have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Rifampin and Apixaban. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Rifampin speeds up the process of removing apixaban from your body. This can leave you with too little medicine to prevent a stroke or blood clot.
FDA Label Information
7.2 Combined P-gp Strong CYP3A4 Inducers Avoid concomitant use of apixaban tablets with combined P-gp and strong CYP3A4 Inducers (e.g., rifampin, carbamazepine, phenytoin, St.
Rifampin Also Interacts With
- Darunavir major
- Bictegravir/Emtricitabine/Tenofovir major
- Glecaprevir/Pibrentasvir major
- Nirmatrelvir/Ritonavir major
- Pitavastatin major
Apixaban Also Interacts With
- Clopidogrel moderate
- Aspirin moderate
- Warfarin moderate
- Carbamazepine moderate
- Heparin moderate
Frequently Asked Questions
What SPL severity band is on file for Rifampin + Apixaban?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Rifampin has 137 labeled pairs on file vs Apixaban's 12. In the moderate band specifically: Rifampin has 26 (also Doxycycline, Probenecid, Theophylline, Aprepitant); Apixaban has 9 (also Clopidogrel, Aspirin, Warfarin, Carbamazepine).
What mechanism field is on file for Rifampin and Apixaban?
Rifampin speeds up the process of removing apixaban from your body. This can leave you with too little medicine to prevent a stroke or blood clot.
Rifampin carries more major-labeled pairs than Apixaban
SPL source-record counts only. This page's band is moderate · classes on file: Rifampin (Rifamycin Antibiotic); Apixaban (Direct Oral Anticoagulant (Factor Xa Inhibitor)).
Rifampin has 8 major-labeled pairs vs Apixaban's 0. This page itself is in the moderate band, not the major band.
8 major · 26 moderate · 103 minor · 137 total
- Other moderate peers for Rifampin
- Doxycycline
- Probenecid
- Theophylline
- Aprepitant
0 major · 9 moderate · 3 minor · 12 total
- Other moderate peers for Apixaban
- Clopidogrel
- Aspirin
- Warfarin
- Carbamazepine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.