Midazolam and Ranitidine Interaction
Drug interaction information between Midazolam and Ranitidine.
Midazolam and Ranitidine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Midazolam and Ranitidine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Ranitidine can cause midazolam levels to build up in your body. This happens because the drug is processed more slowly than usual.
FDA Label Information
Other Drug Interactions Caution is advised when midazolam is administered concomitantly with drugs that are known to inhibit the P450-3A4 enzyme system such as cimetidine (not ranitidine), erythromycin, diltiazem, verapamil, ketoconazole and itraconazole. The effect of single oral doses of 800 mg cimetidine and 300 mg ranitidine on steady-state concentrations of midazolam was examined in a randomized crossover study (n=8). Ranitidine increased the mean steady-state concentration to 62 ng/mL.
Midazolam Also Interacts With
- Darunavir major
- Itraconazole major
- Nirmatrelvir/Ritonavir major
- Ketoconazole moderate
- Verapamil moderate
Ranitidine Also Interacts With
- Risperidone major
- Theophylline major
- Valproate major
- Clonazepam minor
- Darunavir minor
Frequently Asked Questions
What SPL severity band is on file for Midazolam + Ranitidine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Midazolam has 39 labeled pairs on file vs Ranitidine's 15. In the moderate band specifically: Midazolam has 9 (also Ketoconazole, Verapamil, Erythromycin, Cimetidine); Ranitidine has 1.
What mechanism field is on file for Midazolam and Ranitidine?
Ranitidine can cause midazolam levels to build up in your body. This happens because the drug is processed more slowly than usual.
Midazolam's labeled portfolio outnumbers Ranitidine
SPL source-record counts only. This page's band is moderate · classes on file: Midazolam (Benzodiazepine); Ranitidine (H2 Receptor Antagonist).
3 major · 9 moderate · 27 minor · 39 total
- Other moderate peers for Midazolam
- Ketoconazole
- Verapamil
- Erythromycin
- Cimetidine
3 major · 1 moderate · 11 minor · 15 total
Ranitidine has no other moderate-band peer in this dataset besides Midazolam.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.