Midazolam and Cimetidine Interaction
Drug interaction information between Midazolam and Cimetidine.
Midazolam and Cimetidine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Midazolam and Cimetidine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Cimetidine blocks the liver enzyme that breaks down midazolam, which increases the amount of midazolam in your blood. This can make the sedative effects of the medicine much stronger.
FDA Label Information
Other Drug Interactions Caution is advised when midazolam is administered concomitantly with drugs that are known to inhibit the P450-3A4 enzyme system such as cimetidine (not ranitidine), erythromycin, diltiazem, verapamil, ketoconazole and itraconazole. The effect of single oral doses of 800 mg cimetidine and 300 mg ranitidine on steady-state concentrations of midazolam was examined in a randomized crossover study (n=8). Cimetidine increased the mean midazolam steady-state concentration from 57 to 71 ng/mL.
Midazolam Also Interacts With
- Darunavir major
- Itraconazole major
- Nirmatrelvir/Ritonavir major
- Ketoconazole moderate
- Verapamil moderate
Cimetidine Also Interacts With
- Levofloxacin major
- Posaconazole major
- Risperidone major
- Valproate major
- Empagliflozin moderate
Frequently Asked Questions
What SPL severity band is on file for Midazolam + Cimetidine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cimetidine has 77 labeled pairs on file vs Midazolam's 39. In the moderate band specifically: Midazolam has 9 (also Ketoconazole, Verapamil, Erythromycin, Ranitidine); Cimetidine has 10 (also Empagliflozin, Empagliflozin/Linagliptin, Ertugliflozin, Hydroxychloroquine).
What mechanism field is on file for Midazolam and Cimetidine?
Cimetidine blocks the liver enzyme that breaks down midazolam, which increases the amount of midazolam in your blood. This can make the sedative effects of the medicine much stronger.
Cimetidine carries more major-labeled pairs than Midazolam
SPL source-record counts only. This page's band is moderate · classes on file: Midazolam (Benzodiazepine); Cimetidine (H2 Receptor Antagonist).
Cimetidine has 4 major-labeled pairs vs Midazolam's 3. This page itself is in the moderate band, not the major band.
3 major · 9 moderate · 27 minor · 39 total
- Other moderate peers for Midazolam
- Ketoconazole
- Verapamil
- Erythromycin
- Ranitidine
4 major · 10 moderate · 63 minor · 77 total
- Other moderate peers for Cimetidine
- Empagliflozin
- Empagliflozin/Linagliptin
- Ertugliflozin
- Hydroxychloroquine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.