What the FDA labels say about taking them together
Ketoconazole and venlafaxine
Venlafaxine's FDA label (Venlafaxine Hydrochloride) of July 31, 2025 names ketoconazole in its drug interactions section; the ketoconazole label PlainMeds reads does not name venlafaxine. The venlafaxine label: “Increase in Haloperidol AUC and C max. Ketoconazole: Increase in venlafaxine and O-desmethylvenlafaxine AUC and C max.”
Check it at the source: the ketoconazole FDA label on DailyMed (effective January 28, 2026, E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC); the venlafaxine FDA label on DailyMed (effective August 15, 2023, Viatris Specialty LLC).
What does the ketoconazole label say about venlafaxine?
Ketoconazole's label (effective January 28, 2026) does not name venlafaxine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (ketoconazole), E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC, effective January 28, 2026 (SPL set cad7c647-34a9-4e4e-83b3-8d78e58f588f), via openFDA; the full label on DailyMed
What does the venlafaxine label say about ketoconazole?
Venlafaxine Hydrochloride label (Trigen Laboratories, LLC, July 31, 2025), drug interactionsIncrease in Haloperidol AUC and C max. ( 7.4 ) Ketoconazole: Increase in venlafaxine and O-desmethylvenlafaxine AUC and C max.
Source: FDA drug label (Venlafaxine Hydrochloride, NDA022104), Trigen Laboratories, LLC, effective July 31, 2025 (SPL set fdaed1c2-dd0a-4bf3-975a-86fe3e7f0c97), via openFDA
Source: FDA drug label (Effexor XR), NDA020699 (Upjohn), as published by Viatris Specialty LLC, effective August 15, 2023 (SPL set c848a5d8-ba94-4c84-80e3-0bf35fb8e32e), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ketoconazole | Venlafaxine | |
|---|---|---|
| Labeled for | Fungal infections | Depression, Anxiety |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.249 per gram 2% cream | $0.0799 per capsule 75 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once