Simvastatin and Darunavir Interaction
Drug interaction information between Simvastatin and Darunavir.
Simvastatin and Darunavir have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Simvastatin and Darunavir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Darunavir is a medicine that prevents your body from clearing simvastatin out of your system. This leads to much higher levels of simvastatin in your body than normal.
FDA Label Information
Examples: Select azole anti-fungals (e.g., itraconazole, ketoconazole, posaconazole, and voriconazole), select macrolide antibiotics (e.g., erythromycin and clarithromycin, telithromycin), select HIV protease inhibitors (e.g., nelfinavir, ritonavir, and darunavir/ritonavir), select HCV protease inhibitors (e.g., boceprevir and telaprevir), cobicistat-containing products, and nefazodone.
Simvastatin Also Interacts With
- Diltiazem major
- Verapamil major
- Cyclosporine major
- Amiodarone major
- Dronedarone major
Darunavir Also Interacts With
- Lovastatin major
- Sildenafil major
- Lurasidone major
- Pimozide major
- Midazolam major
Frequently Asked Questions
What SPL severity band is on file for Simvastatin + Darunavir?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Darunavir has 101 labeled pairs on file vs Simvastatin's 41. In the minor band specifically: Simvastatin has 21 (also Fenofibrate, Ketoconazole, Erythromycin, Clarithromycin); Darunavir has 70 (also Amlodipine, Metoprolol, Sertraline, Rosuvastatin).
What mechanism field is on file for Simvastatin and Darunavir?
Darunavir is a medicine that prevents your body from clearing simvastatin out of your system. This leads to much higher levels of simvastatin in your body than normal.
Darunavir carries more major-labeled pairs than Simvastatin
SPL source-record counts only. This page's band is minor · classes on file: Simvastatin (HMG-CoA Reductase Inhibitor (Statin)); Darunavir (HIV Protease Inhibitor).
Darunavir has 15 major-labeled pairs vs Simvastatin's 11. This page itself is in the minor band, not the major band.
11 major · 9 moderate · 21 minor · 41 total
- Other minor peers for Simvastatin
- Fenofibrate
- Ketoconazole
- Erythromycin
- Clarithromycin
15 major · 16 moderate · 70 minor · 101 total
- Other minor peers for Darunavir
- Amlodipine
- Metoprolol
- Sertraline
- Rosuvastatin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.