What the FDA labels say about taking them together
Cyclosporine and fenofibrate
Cyclosporine's FDA label of August 10, 2026 names fenofibrate in its drug interactions section, and fenofibrate's label names cyclosporine too. The fenofibrate label: “Immunosuppressants such as cyclosporine and tacrolimus can produce nephrotoxicity with decreases in creatinine clearance and rises in serum creatinine, and because renal excretion is the primary elimination route of …”
Check it at the source: the cyclosporine FDA label on DailyMed (effective August 10, 2026, Novartis Pharmaceuticals Corporation); the fenofibrate FDA label on DailyMed (effective April 29, 2024, A-S Medication Solutions).
What does the cyclosporine label say about fenofibrate?
Cyclosporine label, drug interactionsciprofloxacin; melphalan; amphotericin B; azapropazon; cimetidine; tacrolimus; fibric acid derivatives (e.g., bezafibrate, fenofibrate)
Source: FDA drug label (Neoral), Novartis Pharmaceuticals Corporation, effective August 10, 2026 (SPL set 94461af3-11f1-4670-95d4-2965b9538ae3), via openFDA; the full label on DailyMed
What does the fenofibrate label say about cyclosporine?
Fenofibrate label, drug interactionsImmunosuppressants such as cyclosporine and tacrolimus can produce nephrotoxicity with decreases in creatinine clearance and rises in serum creatinine, and because renal excretion is the primary elimination route of fibrate drugs including TRICOR, there is a risk that an interaction will lead to deterioration of renal function.
Source: FDA drug label (Antara, NDA021695), Lupin Pharmaceuticals, Inc., effective October 1, 2025 (SPL set 24790a18-0291-4b88-a724-acac43b616ce), via openFDA
Source: FDA drug label (Lipofen, NDA021612), ANI Pharmaceuticals, Inc., effective May 12, 2026 (SPL set 78b789b9-854f-46b9-97f3-a48759a6ff89), via openFDA
Source: FDA drug label (Tricor), NDA021656 (Abbvie), as published by A-S Medication Solutions, effective April 29, 2024 (SPL set 84b2af1b-365e-4723-ac5f-bc826ec47772), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cyclosporine | Fenofibrate | |
|---|---|---|
| Labeled for | Organ transplant rejection, Rheumatoid arthritis | High cholesterol, High triglycerides |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $1.04 per unit 0.05% eye emulsion | $0.103 per tablet 160 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once