Fenofibrate and Cyclosporine Interaction
Drug interaction information between Fenofibrate and Cyclosporine.
Fenofibrate and Cyclosporine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Fenofibrate and Cyclosporine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Cyclosporine can damage the kidneys, and because the body uses the kidneys to get rid of fenofibrate, taking both together can cause kidney function to drop.
FDA Label Information
7.2 Immunosuppressants Immunosuppressants such as cyclosporine and tacrolimus can produce nephrotoxicity with decreases in creatinine clearance and rises in serum creatinine, and because renal excretion is the primary elimination route of fibrate drugs including fenofibrate, there is a risk that an interaction will lead to deterioration of renal function.
Fenofibrate Also Interacts With
- Colchicine moderate
- Bempedoic Acid moderate
- Bempedoic Acid/Ezetimibe moderate
- Ezetimibe minor
- Ezetimibe/Simvastatin minor
Cyclosporine Also Interacts With
- Clarithromycin major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Pitavastatin major
- Simvastatin major
Frequently Asked Questions
What SPL severity band is on file for Fenofibrate + Cyclosporine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cyclosporine has 89 labeled pairs on file vs Fenofibrate's 9. In the moderate band specifically: Fenofibrate has 4 (also Colchicine, Bempedoic Acid, Bempedoic Acid/Ezetimibe); Cyclosporine has 24 (also Aliskiren, Allopurinol, Amiloride, Amlodipine/Valsartan).
What mechanism field is on file for Fenofibrate and Cyclosporine?
Cyclosporine can damage the kidneys, and because the body uses the kidneys to get rid of fenofibrate, taking both together can cause kidney function to drop.
Cyclosporine carries more major-labeled pairs than Fenofibrate
SPL source-record counts only. This page's band is moderate · classes on file: Fenofibrate (Fibrate); Cyclosporine (Calcineurin Inhibitor (Immunosuppressant)).
Cyclosporine has 5 major-labeled pairs vs Fenofibrate's 0. This page itself is in the moderate band, not the major band.
0 major · 4 moderate · 5 minor · 9 total
- Other moderate peers for Fenofibrate
- Colchicine
- Bempedoic Acid
- Bempedoic Acid/Ezetimibe
5 major · 24 moderate · 60 minor · 89 total
- Other moderate peers for Cyclosporine
- Aliskiren
- Allopurinol
- Amiloride
- Amlodipine/Valsartan
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.