Fenofibrate and Rosuvastatin Interaction
Drug interaction information between Fenofibrate and Rosuvastatin.
Fenofibrate and Rosuvastatin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Fenofibrate and Rosuvastatin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these medications can cause muscle damage as a side effect. Taking them together increases the risk of developing muscle pain or weakness.
FDA Label Information
Fenofibrates (e.g., fenofibrate and fenofibric acid) Clinical Impact: Fibrates may cause myopathy when given alone.
Fenofibrate Also Interacts With
- Cyclosporine moderate
- Colchicine moderate
- Bempedoic Acid moderate
- Bempedoic Acid/Ezetimibe moderate
- Ezetimibe minor
Rosuvastatin Also Interacts With
- Sofosbuvir/Velpatasvir major
- Glecaprevir/Pibrentasvir major
- Febuxostat major
- Cyclosporine moderate
- Ledipasvir/Sofosbuvir moderate
Frequently Asked Questions
What SPL severity band is on file for Fenofibrate + Rosuvastatin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Rosuvastatin has 21 labeled pairs on file vs Fenofibrate's 9. In the minor band specifically: Fenofibrate has 5 (also Ezetimibe, Ezetimibe/Simvastatin, Rosuvastatin/Ezetimibe, Simvastatin); Rosuvastatin has 10 (also Warfarin, Brexpiprazole, Darunavir, Estradiol).
What mechanism field is on file for Fenofibrate and Rosuvastatin?
Both of these medications can cause muscle damage as a side effect. Taking them together increases the risk of developing muscle pain or weakness.
Rosuvastatin carries more major-labeled pairs than Fenofibrate
SPL source-record counts only. This page's band is minor · classes on file: Fenofibrate (Fibrate); Rosuvastatin (HMG-CoA Reductase Inhibitor (Statin)).
Rosuvastatin has 3 major-labeled pairs vs Fenofibrate's 0. This page itself is in the minor band, not the major band.
0 major · 4 moderate · 5 minor · 9 total
- Other minor peers for Fenofibrate
- Ezetimibe
- Ezetimibe/Simvastatin
- Rosuvastatin/Ezetimibe
- Simvastatin
3 major · 8 moderate · 10 minor · 21 total
- Other minor peers for Rosuvastatin
- Warfarin
- Brexpiprazole
- Darunavir
- Estradiol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.